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It is best if you take Xenical with the meal, but you can take it up to an hour after the meal, if necessary (taking it later than one hour after the meal will make it less effective). This site does not dispense medical advice or advice of any kind. Xenical can decrease the absorption of certain vitamins from the diet. Site users seeking medical advice about their specific situation should consult with their own physician. Therefore, it is recommended that you take a multivitamin once a day, at least two hours before or after Xenical. Food and Drug Administration, Center for Drug Evaluation and Research. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. Often, bedtime is a good time for many people to take their multivitamin during treatment with Xenical. South San Francisco, CA: Genentech USA, Inc.;2013 October. 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Xenical is used to aid in weight loss, or to help reduce the risk of regaining weight already lost. This medicine must be used together with a reduced-calorie diet and is to used only by adults. Xenical is the prescription-strength form of orlistat. You should not use this medicine if you have a digestive disorder (problems absorbing food). The alli brand of orlistat is available without a prescription. You should not use Xenical if you have gallbladder problems, or if you are pregnant. Do not use alli if you have had an organ transplant, if you use cyclosporine, or if you are not overweight. Xenical is only part of a complete program of treatment that also includes diet, exercise, and weight control. 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