Dr Susan Mayou is a consultant dermatologist at London's Lister Hospital and Queen Mary University Hospital. She says: When a patient has badly sun-damaged skin, I usually advise the prescription-only products Retin-A or Retinova - vitamin A derivatives - because there is good medical evidence that these creams improve fine lines and wrinkles around the eyes and across the upper lip. But they must be used diligently for around two years to see any real effect. There can also be side-effects - redness, irritation and peeling. As far as I know, there have been no equivalent medical trials for Retinol, although individuals do report benefits of skin texture and wrinkles. However, Retinol is nothing like as strong as Retin-A or Retinova. 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You can also buy something called A313 in France which is an over the counter Vitamin A gel thing. It's worth remembering that you should discontinue Vit A for a month or so every 6 months as it will stop having an effect as your skin gets used too it. I had a similar issue and have 3 cancerous lesions removed over 2 years. Boots do a private prescription for Differin, it's about £25 a tube, but goes down the more you buy in one transaction. Make sure you wear a facial sunscreen while using Vit A products. Ive seen the differin, but from my understanding its slightly different and is only really effective on acne and not so much for overall cellular turnover. Am a bit wary with some OTC skincare products, seems like they never have much of the active ingredient and it's all humectants Hey, I'm a trained facialist (what the Yanks call an "aesthetician") and retin-A isn't your only option. In fact it's a bit fucking powerful to be using as your first option. 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