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Clomid Clomiphene for Males Increases LH FSH Testosterone. tamoxifen depression This leads to a decrease in testosterone and therefore decreased production of sperm. Because Clomid blocks estrogen's interaction with the. A physician may prescribe Clomid for men with low sperm counts. FSH leads to an increase in sperm production and LH leads to an increase in testosterone production. A man can over-respond to Clomid by making too much testosterone.