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    The entered address, city, state, or zip was not found. Note: Some pharmacies do not allow the savings card to be used for opioid drugs. For information regarding participating pharmacies located within a medical facility, please contact customer care at 1-800-407-8156. Location information is unavailable Please enter your address, city, state, or zip in the field provided. Please enter your address, city, state, or zip in the field provided. Please enter your address, city, state, or zip in the field provided. Promethazine was developed in the mid-1940s when a team of scientists from the French chemical manufacturing company Rhône-Poulenc combined phenothiazine and a diamine side chain of diphenhydramine to create a new drug. Their creation, promethazine, is a synthetic medication that belongs to a pharmaceutical family known as phenothiazines. As a medication, promethazine has several uses, including treating allergies, motion sickness, and more. It is also a strong sedative that is sometimes prescribed during labor, before and after surgery, and at other times. Promethazine is a first generation antihistamine that is only available by prescription. It effectively treats several conditions, such as: As an antihistamine, promethazine competes with histamine for binding at some of its receptor sites (H1-receptors), thereby blocking histamine from binding to many. This, in turn, prevents or reduces the typical effects of histamine activating those receptors, including hives, constriction of the airways, nausea, increased wakefulness, nasal congestion, sneezing, and a runny nose.

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