Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Is hydroxychloroquine used for osteoarthritis Chloroquine and prescribing information Substitutes and alternatives to Plaquenil hydroxychloroquine for uses like Rheumatoid arthritis, Lupus and Malaria Plaquenil hydroxychloroquine Alternatives & Similar Drugs - Skip to full site navigation Dr. Kim responded Nothing safer. Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Hello! Here is a short list Prednisone, Imuran, Remicade, Methotrexate Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil substitute Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, What can substitute plaquenil hydroxychloroquine. Chloroquine tabletIs hydroxychloroquine a narcotic Is there a drug that I can take to replace plaquenil? Asked by tanner01. there are several drugs now that you can take instead of the plaquenil. these type of drugs they have now work in a different way then the methotrexate and plaquenil. most of these drugs you will still take the methotrexate. i researched these drugs before i. Is there a drug that I can take to replace plaquenil?. Alternatives to plaquenil Anti-Inflammatories.. Natural" alternative to Plaquenil. - HealthBoards. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. Cindy, it depends on what kinds of problems you have with your retinas. Plaquenil will on rare occasions cause little deposits to form in retinas that will affect vision. My opthamologist said that I should watch for any changes in color vision, as that would most likely be the first noticeable change. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms.