Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil sore mouth Plaquenil and tingling hands I believe this has been mentioned a while back, but thought I'd ask again who has gotten small brown spots on their skin after sun exposure? I've been on Plaquenil about 2 months, and it has helped my knee/back pain, which is wonderful! Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. Apr 30, 2018 The pathogenesis underlying drug-related dyspigmentation can also be categorized into 3 mechanisms, which are 1 drug or drug metabolite deposition in the dermis and epidermis, 2 enhanced melanin production with or without an increase in the number of active melanocytes, and 3 drug-induced postinflammatory changes to skin. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hyperpigmentation plaquenil Skin Pigmentation & darkening., Will you have Skin hyperpigmentation with Plaquenil. Dosing of aralenDoes prednisone and plaquenil work for ankylosing spondylitits Hydroxychloroquine Plaquenil is not a new therapy. It has been used in rheumatology for decades and it's proven a very useful medication. Plaquenil Pigmentation - BJC Health. Drug-Induced Pigmentation Background, Pathophysiology.. Will you have Skin discoloration - bluish with Plaquenil.. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Jul 11, 2017 Porphyria cutanea tarda PCT is a type of porphyria or blood disorder that affects the skin. PCT is one of the most common types of porphyria. It’s sometimes referred to colloquially as vampire. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of.