I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Plaquenil tests Plaquenil side effects diarrhea Is chloroquine available over the counter Welcome to Sclero Forums! It is delightful to have you join us. I think your experience with going off plaquenil is very helpful for the rest of us to know about. You can let go of being angry at yourself, if you want. You didn't know for sure, ahead of time, that your health would worsen when you went off of plaquenil, did you? Hi Mandie, I had these issues both on & off Plaquenil. I believe it was caused by the lupus rather than the meds. But you should NOT throw all your meds away, this type of reaction could be an extension of the psychological issues you are having. If your lupus gets worse because you have stopped your meds, these issues will too. Get help asap. Plaquenil is supposed to stay in your system for 1-2 months after you stop taking it. Try to rest, stay hydrated and away from sick ppl for now and hopefully you will not have any issues ranin02 August 26, 2016, am #3 I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Do you have to be weaned off of plaquenil Healthboards - Immune & Autoimmune - Lupus tapering Plaquenil, Does Plaquenil affect your temperament? - LUPUS UK Chloroquine base molecular weightDmards plaquenil methotrexateHydroxychloroquine weightHydroxychloroquine shingles Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Prednisone and Plaquenil question" Lupus Community - Support Group. Stopping Plaquenil - General Discussion - Life With Lupus. Protecting your eyesight when taking Plaquenil Lupus.. One of our community members who is taking the DMARD, Placquenil, asked for advice on stopping her adjunctive steroid treatment. Community question Do you have any advice on weaning off of prednisone? I started Placquenil treatment 7 weeks ago, and my doctor wants me to stop taking prednisone. Does anyone know if you have to be weaned off Plaquenil? I've been on it for 15 years, for Lupus? Asked by Lupie523 Updated 27 September 2018 Topics plaquenil, lupus erythematosus, insomnia, sjogren's syndrome, systemic lupus erythematosus, vision Been on Plaquenil only for ten years for sarcoidosis. Once in awhile I also had to have a burst of prednisone. I have been weaning off since my sarcoidosis has been stable for eight years. I went from 400 mg. Daily to 200 daily to 200 every other day over the course of six months. I stopped it about 10 days ago and I feel like I’m 90 years old.