Sertraline breastfeeding

Discussion in 'Rx Online' started by Wardal, 14-Sep-2019.

  1. sulvbut Well-Known Member

    Sertraline breastfeeding


    We examined the risk-benefit profile of sertraline treatment during breastfeeding, summarized the available literature on sertraline use, presented previously unpublished data, and performed a correlation-based meta-analysis of sertraline serum levels in mother-infant pairs. We conducted a search of Pub Med and the National Library of Medicine Lact Med database. We performed a meta-analysis to examine correlations between maternal and infant serum sertraline levels in the existing literature and in previously unpublished data. Of 167 available infant sertraline levels, 146 (87.4 %) were below the limit of detection, and the meta-analysis found no significant relationship between maternal and infant sertraline concentrations. Of 150 infant desmethylsertraline levels, 105 (70.0 %) were below the limit of detection. The correlation analysis revealed a significant relationship between maternal and infant desmethylsertraline concentrations, but this metabolite has only a fraction of the activity of sertraline. A significant relationship was also found for the sum of sertraline and desmethylsertraline, which stems primarily from the contribution of desmethylsertraline. uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website.

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    Sertraline and breastfeeding If your doctor or health visitor says your baby is healthy, sertraline is one of the preferred antidepressants to take when breastfeeding. It has been used by many breastfeeding mothers without any problems. Zoloft sertraline is rated and L2-probably compatible. Zoloft has been extensively studied and the data is consistent that the levels found in breast milk are very low. The amount that transfers into breast milk is only 0.4-2.2% of moms dose. Safe While Breastfeeding Zoloft is considered one of the safer antidepressants for breastfeeding mothers. The SSRI is not present in detectable amounts in blood serum testing. Infants with impaired metabolic function may accumulate Zoloft. Risks of taking Zoloft while breastfeeding should be discussed when metabolic impairment is diagnosed.

    Breastfeeding and human milk are the normative standards for infant feeding and nutrition. Given the documented short- and long-term medical and neurodevelopmental advantages of breastfeeding, infant nutrition should be considered a public health issue and not only a lifestyle choice. The American Academy of Pediatrics reaffirms its recommendation of exclusive breastfeeding for about 6 months, followed by continued breastfeeding as complementary foods are introduced, with continuation of breastfeeding for 1 year or longer as mutually desired by mother and infant. Medical contraindications to breastfeeding are rare. Infant growth should be monitored with the World Health Organization (WHO) Growth Curve Standards to avoid mislabeling infants as underweight or failing to thrive. Hospital routines to encourage and support the initiation and sustaining of exclusive breastfeeding should be based on the American Academy of Pediatrics-endorsed WHO/UNICEF “Ten Steps to Successful Breastfeeding.” National strategies supported by the US Surgeon General’s Call to Action, the Centers for Disease Control and Prevention, and The Joint Commission are involved to facilitate breastfeeding practices in US hospitals and communities. Pediatricians play a critical role in their practices and communities as advocates of breastfeeding and thus should be knowledgeable about the health risks of not breastfeeding, the economic benefits to society of breastfeeding, and the techniques for managing and supporting the breastfeeding dyad. The “Business Case for Breastfeeding” details how mothers can maintain lactation in the workplace and the benefits to employers who facilitate this practice. These doses correspond to approximately 4 times the maximum recommended human dose (MRHD) on a mg/m basis. The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. Molecular weight:342.7 CATEGORY: C "Reproduction studies have been performed in rats and rabbits at doses up to 80 mg/kg/day and 40 mg/kg/day, respectively. There was no evidence of teratogenicity at any dose level. When pregnant rats and rabbits were given sertraline during the period of organogenesis, delayed ossification was observed in fetuses at doses of 0.5 times the MRHD in rats and 4 times the MRHD in rabbits. When female rats received sertraline at a dose of 20 mg/kg (1 times the MRHD) during the last third of gestation and throughout lactation, there was an increase in the number of stillborn pups and in the number of pups dying during the first 4 days after birth." [1]. Birth outcomes after prenatal exposure to antidepressant medication. Transplacental passage in humans has been demonstrated with a mean ratio of cord to maternal serum concentration of 0.29 (range 0.10 to 0.66) after maternal doses of 25 to 150 mg day [2]. A prospective study of women followed by The California Teratogen Information Service found no increase in the rate of major anomalies in the infants of 112 women who had used sertraline during pregnancy when compared to nonexposed controls.

    Sertraline breastfeeding

    Zoloft And Breastfeeding? - Circle of Moms, Zoloft and breastfeeding - InfantRisk Forums

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  6. The highest concentrations of sertraline and desmethylsertraline were observed 8 to 9 hours after maternal ingestion6. In another study of eight women taking sertraline the milk/plasma ratios of 1.93 and 1.64 were estimated for sertraline and N-desmethylsertraline respectively.

    • Sertraline Zoloft ® in Pregnancy and Breastfeeding.
    • Zoloft During Pregnancy and Breastfeeding.
    • Is It Safe to Take Zoloft While Breastfeeding? - MomJunction.

    Sertraline and Breast-Feeding. This article has no abstract; the first 100 words appear below. To the Editor Postpartum depression occurs in approximately 10 percent of women who give birth and. Sep 1, 2017. Can taking sertraline during my pregnancy cause birth defects. There are several published reports on sertraline and breastfeeding, with. Antidepressant Use During Pregnancy and Breastfeeding. The lowest ratios were for sertraline Zoloft and paroxetine Paxil, and the highest for citalopram.

     
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