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    El fármaco restaura la respuesta normal a la estimulación sexual. Propio, el mecanismo fisiológico que proporciona una erección, no es posible sin el aislamiento de óxido nítrico en el cuerpo cavernoso durante la estimulación sexual. El mismo activa una enzima especial llamada guanilatociclasa, lo que resulta en un aumento de los niveles de c GMP (monofosfato de guanosina cíclico), relajando los músculos del cuerpo cavernoso y aumentando el flujo sanguíneo a los genitales. Sildenafiles un ingrediente activo de VIAGRA, es un inhibidor selectivo de la PDE5 (fosfodiesterasade tipo 5), que presenta un desglose de c GMP en el cuerpo cavernoso. El fármaco se caracteriza por la acción periférica en la erección del pene. Es de destacar que sildenafil relaja el cuerpo cavernoso no directamente, sino que utiliza la función de relajar el óxido de nitrógeno. Se sabe que para una acción farmacológica útil del fármaco es necesaria la estimulación sexual. Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

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