Hydroxychloroquine toxicity autofluorescence

Discussion in 'Plaquenil Generic' started by Grifon, 12-Mar-2020.

  1. sram77 Well-Known Member

    Hydroxychloroquine toxicity autofluorescence


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Fundus Autofluorescence Is Not the Best Early Screen for Hydroxychloroquine Toxicity—Reply Ian R. Gorovoy, MD; Mark S. Gorovoy, MD Fundus autofluorescence images of the left eye of a 59-year-old women with sarcoidosis who received 200 mg of hydroxychloroquine sulfate twice daily for 15 years. Ocular findings of HCQ retinal toxicity as detected by various screening modalities. A female patient was diagnosed with HCQ retinal toxicity at the age of 53 years, having taken HCQ for 12 years at 400 mg/day. Evaluating Hydroxychloroquine Toxicity With Multifocal Electroretinography Toxicity first affects small areas of the retina. BY DONNELL J. CREEL, PhD Figure 1. Fundus photograph using autofluorescence to better designate retinal damage in the macula. This example depicts late-stage severe toxic effects.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine toxicity autofluorescence

    Retina Today - Evaluating Hydroxychloroquine Toxicity With., Hydroxychloroquine-related retinal toxicity Rheumatology.

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  4. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects.

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    In early toxicity, 75 % developed progression after drug cessation, including disruption of the parafoveal EZ and retinal pigment epithelium and thinning of the ONL. Eyes with obvious toxicity had greater inferior outer ring thinning 12 months after drug cessation compared to early toxicity p = 0.002, 95 % CI −2 to −8 μm. Although multifocal electroretinogram mfERG and fundus autofluorescence FAF are not currently primary tests used in the evaluation of Plaquenil retinal toxicity, they may be beneficial when the diagnosis or findings are enigmatic or an adjunct test is warranted. Plaquenil Hydroxychloroquine Toxicity Condition/keywords plaquenil toxicity Imaging device Optical coherence tomography system Autofluorescence Description 68-year-old female with 15 year history of plaquenil hydroxychloroquine use. Related files

     
  5. ssilka Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Alfa Aesar Chloroquine diphosphate salt, 98% Fisher. Chloroquine - FDA prescribing information, side effects and uses Chloroquine Indications, Side Effects, Warnings -
     
  6. deff Moderator

    Sarcoidosis and Plaquenil - Sarcoidosis - Inspire Plaquenil was the 1st treatment outside of prednisone that I tried. And I've been on 400 mg from the start. I did fine on it for a quite a while until the sarc joint pain became full fledged rheumatoid arthritis and I had to add something else.

    Effectiveness of Chloroquine and Hydroxychloroquine in.