Chloroquine mechanism of resistance

Discussion in 'Pharmacy Northwest Canada' started by Muhandis, 15-Mar-2020.

  1. pulp User

    Chloroquine mechanism of resistance


    However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same.

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    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion. The combination of chloroquine with zinc enhanced chloroquine’s cytotoxicity and induced apoptosis in A2780 cells. Thus chloroquine is a zinc ionophore, a property that may contribute to chloroquine’s anticancer activity. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Chloroquine Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines.

    These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant Plasmodium falciparum. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

    Chloroquine mechanism of resistance

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  7. Aug 24, 2017 Taken together, our data indicate that CQ effectively targets the lysosome to sensitise towards cell death but is prone to a glucose-dependent resistance mechanism, thus providing rationale for.

    • Lysosomotropism depends on glucose a chloroquine resistance..
    • History of antimalarials Medicines for Malaria Venture.
    • Efflux of chloroquine from Plasmodium falciparum..

    Resistance to chloroquine has, however, steadily spread since the 1960s from two foci, one in South America and one in South East Asia. Throughout the 1980s, chloroquine resistance spread through Africa, the global heartland of malaria mortality and morbidity, and there are very few effective and affordable drugs to take its place. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 3.4.1 Biological influences on resistance 13 Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

     
  8. ExTester User

    Hydroxychloroquine is the cornerstone of the medical management of systemic lupus erythematosus (SLE). The Role of Hydroxychloroquine Blood Levels in SLE RheumNow. Common and Rare Side Effects for Plaquenil Oral What is the blood work protocol while taking.
     
  9. vasisualii Well-Known Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Will you have Platelet count increased with Plaquenil - eHealthMe Hydroxychloroquine-Induced Retinal Toxicity - American. Effects of Hydroxychloroquine in Patients With Cutaneous.
     
  10. LaCapone Guest

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  11. webcontent New Member

    Plaquenil Hydroxychloroquine for Lupus - LupusCorner To prevent upset stomach, take Plaquenil with food. Also, the generic version of Plaquenil, hydroxychloroquine, can cause additional stomach irritation. If you are experiencing consistent stomach aches, it may be useful to talk to your doctor about taking the brand-name alternative.

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.