Chloroquine apoptosis

Discussion in 'Pharmacy Northwest Canada' started by Slang, 04-Mar-2020.

  1. Chloroquine apoptosis


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Introduction. Chloroquine is an antimalarial drug that has been used in humans for many years 1. In recent years, Chloroquine has been shown to inhibit autophagy and induce apoptosis in malignant cells and thus has been tested in various experimental model systems 2 and in human clinical trials 3, 4. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. Targeting apoptosis, angiogenesis and oxidative stress has also been described as efficient tools in augmenting sunitinib anticancer activity. Chloroquine diphosphate, a well-known anti-malarial drug, has been under focus due to its potential cytotoxicity in human cancer cells.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine apoptosis

    Chloroquine Promotes Apoptosis in Melanoma Cells by., CST - Chloroquine

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  4. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. References. 1.

    • Chloroquine for research Cell-culture tested InvivoGen.
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    Chloroquine CQ and hydroxychloroquine HCQ, two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. Chloroquine CQ, an anti-malarial drug, has immune-modulating activity and lysosomotropic activity. In this study, we investigated CQ sensitizes TRAIL-mediated apoptosis in human renal cancer Caki cells. Jan 27, 2010 Chloroquine CQ, traditionally used as an antimalarial medication, has emerged as a prospective adjunct in tumor therapy. CQ has been found to strongly potentiate the inhibitory effect of radiation on cancer cell proliferation, presumably via negative regulation of DNA repair processes.

     
  5. valdnp Moderator

    He went to see a Rheumi and he said it could be Fibro/Lupus or worst case... This has been so stressful for us as the wait for the bloodwork is the worst. The Rheumi put him on 75 mg of Lyrica to treat him for fibro in case that was it but it knocks my husband out so he can't take it. My sister was diagnosed with scleroderma at age 6 and is extremely ill now at 30 she can barely move-my mother was diagnosed with lupus about 4 years ago and my aunt also suffers from lupus. If I am taking Plaquenil, can I take Advil for a headache? Can Ibuprofen be taken while on Prednisone and Plaquenil. Is it ok to take hYdroxychloroquine and ibuprofen - Answers
     
  6. enthusiast XenForo Moderator

    Is Hydroxychloroquine Plaquenil an Immunosuppressant? — Donovan Hair. Hydroxychloroquine Plaquenil is an oral medication that is commonly used in the treatment of many types of autoimmune conditions including lichen planopilairs, frontal fibrosing alopecia, discoid lupus and pseudopelade. I’m often asked if hydroxychloroquine is an immunosuppressant or best classified as an immunomodulatory drug.

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