Metformin kidney damage

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  1. an4ous Well-Known Member

    Metformin kidney damage


    I was told by my doctor that recent studies on metformin aka glucophage has shown that it does cause kidney damage as well as diabetes, itself. This was news to me and is the reason I have been taken off metformin. I have also told that celebrex also causes damage to the kidneys and I was taken off it, also. I am doing some more research and will get back with links to what I find. I dont know but I know some patients who had kidney failures after taking metformin for a long time, I think u should ask your doctor about it, Ive also read about the benefits of alpha-lipoic acid better ask your doctor also if its a good replacement for metformin Subscribe to free newsletters. By clicking Subscribe, I agree to the Terms & Conditions and Privacy Policy and understand that I may opt out of subscriptions at any time. Just over one year ago here at Diabetes Flashpoints, we discussed the possibility that hundreds of thousands of people with both diabetes and kidney disease might benefit from taking the diabetes drug metformin. As we noted then, this drug has carried a “black box” warning on its label — mandated by the U. Food and Drug Administration (FDA) — ever since it became available in the United States in 1994, due to concerns about lactic acidosis. Lactic acidosis is much more common in people with impaired kidney function. This rare but extremely serious reaction was found to be an unacceptably common side effect of a drug related to metformin — phenformin — which was pulled from the U. Since metformin’s warning label is based, in part, on concerns about a different drug entirely, many researchers have tried to estimate how safe metformin is for people with diabetes whose kidney function is impaired. Last year, we noted that many researchers believe metformin is safe for people with mild to moderate kidney disease, defined as having an estimated glomerular filtration rate (e GFR) of 30–60 ml/min. And one study found that using a safety cutoff of an e GFR of 30 ml/min, nearly one million people in the United States who currently don’t take metformin because of the FDA’s labeling might be able to safely do so. The evidence, it seems, has only grown stronger in favor of metformin being more widely prescribed to people with kidney disease. As noted in a recent article at Diabetes In Control.com, the blood-glucose-lowering benefits of loosening restrictions on metformin could be enormous. One study cited in the article, published last August in the journal Diabetes Care, found that depending on how e GFR is ca Continue reading Abstract Type 2 diabetes mellitus and chronic kidney disease (CKD) frequently co-exist and the increasing burden of both conditions is a global concern.

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    Prior to taking metformin, you should talk to your healthcare provider about any health conditions you might have, such as kidney or liver problems, congestive heart failure, or low vitamin B 12 levels. TUESDAY, Dec. 23, 2014 HealthDay News -- Although metformin, the popular type 2 diabetes medication, is usually not prescribed for people with kidney. Several recent studies have indicated that the diabetes drug metformin may be safe for many people with kidney disease, contrary to FDA guidelines.

    Provided by Expert Zhang Youkang on 2013-01-30 Metformin is commonly used to treat type 2 diabetes. It can help control blood sugar levels by increasing insulin sensitivity, decreasing sugar production by the liver and decreasing sugar absorption. However, if the patients have poor renal function, they should use the medicine with great caution as metformin has side effects on kidney. The metformin residual is excreted out of the body by the kidneys in right condition. When the kidneys are not functioning well, the metformin residual will build up in body in high concentrations which may result in lactic acidosis. Lactic acidosis occurs rarely, but it can be fatal in more than 50% cases and usually occurs in diabetes patients with significant kidney dysfunction. Symptoms of lactic acidosis include weakness, sleepiness, slow heart beat, feeling cold, muscle pain, shortness of breath, loss of consciousness, etc. Metformin, or Glucophage, is a drug commonly used to treat type 2 diabetes mellitus. It is available in both short and long-acting forms. Rx List reports the most common side effects associated with metformin, occurring in more than 5 percent of patients using the drug, are diarrhea, nausea, vomiting, flatulence, diffuse lack of strength, headache, indigestion and abdominal discomfort. Metformin-induced renal side effects are rare but can be lethal. Metformin is excreted out of the body by the kidneys. When the kidneys are not functioning properly, metformin can accumulate in high concentrations which may result in lactic acidosis. Lactic acidosis is a rare, serious metabolic abnormality that occurs with uncontrolled diabetes, severe hypotension as well as high metformin levels.

    Metformin kidney damage

    FDA Drug Safety Communication FDA revises warnings regarding., Diabetes Drug Metformin Safe for Patients With Kidney. -.

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  3. Hi, So sorry to hear about your kidney damage. Metformin does not damage kidneys, that damage is done by high blood sugars. The biggest concern is when metformin is.

    • Metformin and kidney damage - MedHelp.
    • Metformin in People With Kidney Disease - Diabetes..
    • Can Metformin Cause Kidney Failure - Kidney disease.

    Metformin drug is eliminate by kidney. Whenever kidney function is poor at that time this metformin collect in blood and not eliminate easily. It lead lactic can cause kidney is very rarely seen. Doctor always check kidney function In metformin taking drugs. I hope my answer help you. Thank you. I hope that I have provided a bit of history of metformin and kidney disease, information about the risks, and a lot of new information about the potential benefits. Proteinuria is a hallmark of kidney damage and diabetes is one of the main culprits. In a 2008 article in the "American Journal of Hypertension," Cubedda and colleagues reported that the combination of metformin along with a healthy lifestyle may reduce the amount of proteinuria seen in diabetes.

     
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