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It’s advisable to take one pill with a glass of water, and if they suffer from stomach ulcers, they should use this medicine with milk or food, but this combination may reduce its effectiveness. Besides, they shouldn’t lie down for ten minutes after taking Doxycycline. General recommendations for other vaccines to consider during the pre-travel consultation can be found on the CDC Travelers’ Health website (gov/travel). Updated information reflecting changes since publication can be found in the online version of this book (gov/yellowbook) and on the CDC Travelers’ Health website (gov/travel). The information was accurate at the time of publication; however, this information is subject to change at any time as a result of changes in disease transmission or, in the case of YF, changing country entry requirements. Country-specific maps of malaria transmission areas, country-specific maps depicting yellow fever vaccine recommendations, and a reference map of China are included to aid in interpreting the information. Arguin (Malaria) The following pages present country-specific information on yellow fever (YF) vaccine requirements and recommendations (see Table 3-27) and malaria transmission information and prophylaxis recommendations. Since publication of the 2018, large YF outbreaks occurred in eastern Brazil in 20, involving states where YF was not previously considered endemic. Notably, human YF cases occurred within the greater metropolitan area of São Paulo City and not far from the metropolitan limits of Rio de Janeiro City. 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