Plaquenil toxicity on retina

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  1. zakusha Well-Known Member

    Plaquenil toxicity on retina


    Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating.

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    Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.

    Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area).

    Plaquenil toxicity on retina

    Plaquenil Toxicity Screening - Retina Group of New York, Plaquenil Risk Calculators

  2. Chances of having a lupus flare when stopping plaquenil
  3. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body.

    • Plaquenil Toxicity - Symptoms, Treatment, Risk Factors, Retinopathy.
    • Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening.
    • Plaquenil Toxicity - alberta-.

    Retinal toxicity is a very rare side effect of the hydroxychloroquine therapy, but when it has occurred, vision loss may be permanent and may progress even years after the cessation of medication. Patients would be examined every 3 months, then annually, until they are stabled. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.

     
  4. Maxim31 Well-Known Member

    Some side effects may occur that usually do not need medical attention. Plaquenil - Hydroxychloroquine - Side Effects, Dosage, Interactions. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  5. freezippo User

    Chloroquine Oral Route Proper Use - Mayo Clinic To do so may increase the chance of serious side effects. For patients taking chloroquine to prevent malaria Your doctor will want you to start taking this medicine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria.

    Chloroquine MedlinePlus Drug Information
     
  6. Sivilla XenForo Moderator

    Plaquenil for RA?" Rheumatoid Arthritis Community - Support. I am still on 7 mg of Prednisone daily, but am trying to wean slowly. I still have flares now and then, but work full time. I have not had problematic side effects from the Plaquenil or MTX, but the steroids caused weight gain and some hair loss besides what was caused by the arthritis.

    Hydroxychloroquine Lowers Risk of Heart Attack and Stroke.