Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Complete list of side effects of plaquenil Hydroxychloroquine methotrexate drug interactions Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Plaquenil caused a loss of appitite and weight loss for me. Both times I started taking it, the first time it was so serious I had to stop taking it. Started again several years later when I flared again and had loss of appitite and weight loss but a bit more moderate. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss. I took my 3rd dose of mtx this week as well as daily hydroxychloroquine and weekly folic acid. In 3 weeks I have lost just over half a stone. Week 1 I was very nauseous, week 2 improved and this week, I haven't thought about it. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Hydroxychloroquine and weightloss Abnormal Weight Gain and Gut Microbiota Modifications Are., Plaquenil & Weight Gain/Loss Hydroxychloroquine immunosuppressionHydroxychloroquine phosphatePlaquenil make nails brittleChloroquine structure activity relationshipChloroquine resistant salmonella Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine may also be used for purposes not listed in this medication guide. What are the possible side effects of hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Does anyone know if hydroxychloroquine. - HealthUnlocked. Hydroxychloroquine Uses, Dosage & Side Effects -. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Eat 6 meals/day. Work on strength training to build your large muscle groups. Workout w heavier weights w fewer repetitions. Sleep at least 8 to 9 hrs/night. Hydrate well w water. Foods to help w healthy weight gain almonds, cashews, pecans, sunflower seeds, flax seeds, walnuts, hummus. Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some.