He reported a history of tick bite and rash in 2002. The knee pain and other symptoms rapidly improved over the next two weeks. He received a short course of antibiotics at that time. After two weeks he reported that the antibiotics were causing nightmares and insomnia. Then one week later he complained of confusion and unsteadiness. Plaquenil liver enzymes Chloroquine generic Plaquenil nauseus Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Continued Treatment for Chronic Lyme Disease. Sometimes, people go through treatment for Lyme disease but their symptoms feeling run-down and achy don’t go away. Uses In addition to treating malaria, hydroxychloroquine is used for the following systemic conditions and dermatological conditions Systemic and discoid lupus erythematosis; Rheumatoid Arthritis; Idiopathic vasculitis; Post Lyme disease arthritis; Sjögren’s syndrome; Porphyria cutanea tarda; Polymorphous Light Eruption; Graft Versus Host Disease He continued to improve rapidly once more with a cessation of neurocognitive symptoms. When I saw him initially he complained of knee pain and swelling, fatigue, generalized arthralgia (joint pain), numbness and tingling and an irregular heart beat. I diagnosed a "brain Herx." I added Plaquenil back, as well as Welchol, presumptively to remove "neurotoxins." I also reduced the dose of Amoxicillin and Minocin. Plaquenil used for lyme disease Plaquenil Uses - Antibiotics Home Page, Lyme Disease Treatment Medications, Antibiotics, Recovery Time Glutathione plaquenil interactionInappropriate malaria prophylaxis chloroquine resistantChloroquine adverse effects mnemonics Lori, I'm not medically trained, but here's what I find on the internet for your consideration Plaquenil is a drug used to treat malaria and also in autoimmune conditions such as lupus and rheumatoid arthritis. The references I have found as to using it in Lyme treatment combine Plaquenil with another medication at the same time. ARE YOU TAKING PLAQUINIL? - Lyme Disease - MedHelp. Hydroxychloroquine - American Osteopathic College of.. Plaquenil and Lyme - Lyme Disease - MedHelp. Recent publications suggest the efficacy of shorter courses of treatment for early Lyme disease. NOTE For people intolerant of amoxicillin, doxycycline, and cefuroxime axetil, the macrolides azithromycin, clarithromycin, or erythromycin may be used, although they have a lower efficacy. Anyone used hydroxychloroquine ? Support Forums Lyme Disease New Topic Reply. Test is the one to have. I wasn't on Plaquenil but Lyme and cos can affect our eyes and I wanted them checked. I recommend if you're going on Plaquenil to have a baseline test done. MATERIAL/METHODS 235 patients with a multi-symptom complex typical of chronic Lyme disease, ie fatigue, musculoskeletal pain, and neurocognitive dysfunction and with serologic reactivity against B.burgdorferi were treated with a macrolide antibiotic eg clarithromycin and hydroxychloroquine.