Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. How does plaquenil work in the body Plaquenil side effects when starting Retinal photo plaquenil Hydroxychloroquine Plaquenil® is used for rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine Plaquenil® is an antibiotic used to treat malaria, but it also works to treat symptoms of RA, lupus, and other rheumatic diseases. It can reduce your joint pain and swelling. I 21M have been on methotrexate for about a year, before that was on plaquenil. I have some osteopenia in my hands and wrists from the RA, along with some arthritic damage in my spine. And many of the middle joints on my fingers are fatter/puffier than they used to be. That's just how it is with RA, yknow? But I'm still not okay with it. Other than that I have had some GI issues when the Plaquenil was increased, but I seem to now be adjusting to it as well. Both have really helped as my inflammation markers are now back in the normal ranges in my blood work--they were 600 times normal before I began. I still have joint pain, but it is much less than before. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate Methotrexate vs Plaquenil? -, Methotrexate and coronavirus rheumatoid Chloroquine primaquine babesiaToxicity of chloroquinePlaquenil maculopathy guidelines Plaquenil is better than Sulfazalizine but the Arava is still more effective than the Plaq. Can't imagine Plaquenil by itself being very effective for moderate to severe. only good for mild cases. Keep in mind that Arava can really take a full three months to acheive full effectiveness. keep taking Plaq until then. Anyone used plaquenil and arava which is better? DailyStrength. Methotrexate and plaquenil - @Kristinsaba1988.. Effects of methotrexate and hydroxychloroquine combination.. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate is classified as a disease-modifying anti-rheumatic drug DMARD. The drug decreases pain and swelling associated with rheumatoid arthritis, slows progression of the disease, and helps prevent joint damage. When considering effectiveness and safety, is methotrexate injection better than oral methotrexate?