B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plaquenil hydroxychloroquine sulfate Hydroxychloroquine with methotrexate combination Background Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one year after therapy discontinuation L Katie Morrison MD 1,2, James J Nordlund MD 1, Michael P Heffernan MD 1 Dermatology Online Journal 15 12 15 1. Center for Clinical Studies, Houston, Texas 2. Wright State Dermatology, Dayton, Ohio Abstract Reactions 1565, p109 - Cutaneous hyperpigmentation 4 case reports Four men developed cutaneous hyperpigmentation during treatment with doxycycline and hydroxychloroquine routes not stated. A 75-year-old man with chronic Q fever received doxycycline 200 mg/day; he had been receiving hydroxychloroquine 400 mg/day for 5 years for rheumatoid arthritis. After 4 months, his. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Cutaneous hyperpigmentation during therapy with hydroxychloroquine CASE REPORT Cutaneous hyperpigmentation induced by., Persistent cutaneous hyperpigmentation due to. Chloroquine quininePlaquenil 200 mg tablets side effectsWhat is plaquenil prescribed forPlaquenil cumulative dose Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Doxycycline/hydroxychloroquine, Reactions Weekly 10.1007.. Cutaneous Hyperpigmentation During Therapy With.. Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Home April 2007 - Volume 13 - Issue 2 Cutaneous Hyperpigmentation During Therapy With Hydroxychlor. Log in to view full text. If you're not a subscriber, you can Cutaneous hyperpigmentation during therapy with hydroxychloroquine. J Clin Rheumatol 2007; 13 113. Rood MJ, Vermeer MH, Huizinga TW. Hyperpigmentation of the skin due to hydroxychloroquine. Scand J Rheumatol 2008; 37 158. Reynaert S, Setterfield J, Black MM. Hydroxychloroquine-induced pigmentation in two patients with systemic lupus.