Chloroquine natural source

Discussion in 'Northwest Pharmacy Canada' started by prill, 18-Mar-2020.

  1. AMBA Well-Known Member

    Chloroquine natural source


    Quinine is a basic amine and is usually provided as a salt. Various existing preparations include the hydrochloride, dihydrochloride, sulfate, bisulfate and gluconate.

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    Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Quinine is a bitter compound that comes from the bark of the cinchona tree. The tree is most commonly found in South America, Central America, the islands of the Caribbean, and parts of the western coast of Africa. Quinine was originally developed as a medicine to fight malaria. Chloroquine is a synthetic drug made from natural resources like cinchona alkaloids and ginghaosu. chloroquine is the protype antimalarial drug, most widely used to treat all types of malarial infections. it is a safe anti-malarial agent. chlroquine has little effect on the heart in therapeutic doses and hence regular cardiac monitor is not needed. however, it can cause hypotension in the event of overdose. chloroquine stimulates insulin secretion in therapeutic doses it can cause.

    All quinine salts may be given orally or intravenously (IV); quinine gluconate may also be given intramuscularly (IM) or rectally (PR). In the United States, quinine sulfate is commercially available in 324-mg tablets under the brand name Qualaquin.

    Chloroquine natural source

    Chloroquine drug Britannica, Quinine in Tonic Water Is It Safe and What Are the Side.

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  5. This is not a list of all drugs or health problems that interact with chloroquine. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    The current major drawback to using chloroquine to treat fish diseases is locating a commercial source of the drug. Public aquariums, buying large quantities, have no difficulty in acquiring it from online companies at around $185 per kilogram. Sources of drugs may be natural, synthetic, and biosynthetic. Drugs of plant, animal, microbiological, marine, mineral, geographical origins constitute the natural sources. The entire plant, plant parts, secretion, and exudate of plants are the sources of plant drugs. Chloroquine Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines.

     
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