In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Buy chloroquine boots Plaquenil law suits Plaquenil hot flashes Hydroxychloroquine sulfate eye side effects Dec 25, 2011 Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin; Loss of appetite; Abdominal bloating; Upset stomach; Stomach cramps Banded or diffuse pigmentation of nails often occurs; Amiodarone Blue-grey pigmentation in sun-exposed areas face and hands Photosensitivity occurs in 30-57% of patients whilst 1-10% show skin pigmentation; Skin pigmentation is reversible but may take up to one year for complete resolution after the drug has been stopped; NSAIDs Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil skin pigment Ask the Expert Plaquenil and Sjögren’s, Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Plaquenil can they be cut in halfPlaquenil 200 mg uses Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Drug-induced hyperpigmentation DermNet NZ. Plaquenil & skin discoloration -. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling Figure 1.