One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect. Fortunately, very few prescription drugs have any known detrimental effects for people with AMD. Plaquenil and grapefruit Plaquenil side effects bone pain Hydroxychloroquine online Plaquenil, or hydroxychloroquine, is an anti-malaria medication that is commonly used to treat autoimmune disorders like lupus or rheumatoid arthritis. During World War II, it was found that antimalarial drugs helped improve fatigue, fever and skin rashes as well as joint and muscle pain, which are common symptoms in lupus. While Plaquenil can cause toxicity damage to the macula, it will not cause a macular pucker. If you are on Plaquenil, it is recommended that you have your retina checked regularly by an ophthalmologist, including imaging studies, which can help find damage to the macula. The investigators think that there is a connection between the use of plaquenil and the prevention of Age related macular degeneration AMD. The investigators believe that the use of plaquenil makes bruch's membrane thicker, thereby preventing Chroidal Neovascularization CNV growth. Doctors often put patients with certain potentially life-threatening cardiovascular conditions on this blood thinner. Warfarin (Coumadin®), which is an anticoagulant blood thinner, is one exception. Plaquenil use in macular degen Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS, Can Plaquenil cause a macular pucker? - American Academy. Hydroxychloroquine and cancer riskChloroquine transfection lipofectamineAralen dosage lupusPlaquenil and retinal damage Macular degeneration refers to the gradual decline in vision quality, specifically, in the center of the field of vision called the macula, and occurs as a result of damage to the retina. Can taking Plaquenil cause macular degeneration - Answers. Plaqenil Role in Prevention of Age Related Macular.. Macular degeneration in Plaquenil how severe and when it.. The risk for retinal toxicity begins once the patient has used Plaquenil for five to seven years and/or has taken a cumulative dose of more than 1,000g. Patients with renal or hepatic dysfunction are at an increased risk of toxicity. 1 Other risk factors for retinal toxicity include short stature, obesity. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Early hydroxychloroquine macular toxicity. Warner AE. This report describes the case of an appropriately dosed patient who developed maculopathy 8 years after starting hydroxychloroquine HCQ therapy for systemic lupus erythematosus. Risk factors and screening for HCQ-associated maculopathy are discussed.