Chloroquine resistance mechanism of action

Discussion in 'Hydroxychloroquine Sulfate' started by ABSinc, 29-Feb-2020.

  1. MLDseo New Member

    Chloroquine resistance mechanism of action


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    What are the warning on the nnedicine named hydroxychloroquine Hydroxychloroquine immunosuppression Choi et al 2014 chloroquine paclitaxel Aao plaquenil guideline

    Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. Chloroquine acts by interfering with the sequestration of toxic heme ferriprotoporphyrin IX moieties produced when hemoglobin is digested by the intra-erythrocytic parasite to obtain a major.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance mechanism of action

    Chloroquine Indications, Side Effects, Warnings -, Aralen Chloroquine Uses, Dosage, Side Effects.

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  5. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.

    • Chloroquine C18H26ClN3 - PubChem.
    • Antimalarial Drugs Modes of Action snd Mechanisms of..
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.

    Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Of interest, the mechanism of resistance to the antifolate pyrimethamine appears to be similar among most species studied thus far resistance in P. falciparum and in the rodent malarias P. berghei, P. chabaudi and P. yoelii and, more recently, in P. vivax involves point Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein.

     
  6. Grapz Guest

    Atovaquone/Proguanil (Malarone) Adults: 1 adult tablet daily. Malaria Prophylaxis – Malaria Site Chloroquine Oral Uses, Side Effects, Interactions. What Are Malaria Pills? - WebMD
     
  7. scoopayrari XenForo Moderator

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  8. Gridenok User

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis.

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