They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Chloroquine is ineffective on the exoeryhto Plaquenil low dose Amaurosis fugax from plaquenil This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. My husband has been taking Plaquenil generic hydroxychloroquine for almost 2 yrs. under a rheumatologist's care. He has Sjogren's Syndrome. He became very ill, and was diagnosed w/ viral meningial encephalitis. We were much later told that the Plaquenil had "lowered his tolerance to infection, as it is also an immuno-suppressant." Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Plaquenil decrease immune system Stopping plaquenil. DailyStrength, RA and Hydroxychloroquine How Effective is it for Rheumatoid. Do i need a prescription for hydroxychloroquineHydroxychloroquine plaquenil how it workPlaquenil and swollen lymph nodesChloroquine transfection protocol They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Specifically, corticosteroids and TNF tumor necrosis factor. Medications that Weaken Your Immune System and Fungal.. Do either hydroxychol/Plaquenil put you at risk for.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Jun 18, 2015 These observations provide proof of concept that drastically decreasing immune hyperactivation arrests SIV disease progression and turns the virus/immune system balance in favor of the latter. Clinical trials will be required to assess the potential of auranofin to decrease immune activation in ART-treated subjects. The mechanism is unknown. Combining telbivudine Tyzeka and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects. Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines. Nov 28, 2010 Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders.