Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Withdrawal effects of plaquenil Can you take hydroxychloroquine and xanax together Plaquenil crest Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Hydroxychloroquine Sulfate Drug Information from Includes Hydroxychloroquine Sulfate side effects, interactions and indications. Mechanism of action/Effect Antiprotozoal—Malaria Unknown, but may be based on ability of hydroxychloroquine to bind to and alter the properties of DNA. Also has been found to be taken up into the. The understanding that one mechanism of action of hydroxychloroquine is the antagonism of TLR7 and TLR9 signaling is also intriguing, given the postulated roles of IFN-α in endothelial dysfunction and abnormal vascular repair. 177 Prospective studies demonstrating a cardioprotective effect of hydroxychloroquine in patients with SLE are needed. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine action Hydroxychloroquine - Safe In Breastfeeding, Hydroxychloroquine Sulfate Drug Information, Professional Why is hydroxychloroquine so expensivePlaquenil hot flashes Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Hydroxychloroquine - an overview ScienceDirect Topics. Hydroxychloroquine - Wikipedia. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Data from case series and retrospective and open-label studies support the use of hydroxychloroquine in the treatment of extensive cutaneous sarcoidosis Chong 2005, Jones 1990, Modi 2008. Contraindications. Known hypersensitivity to hydroxychloroquine, 4-aminoquinoline derivatives, or any component of the formulation. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.