Although FAF technology has been referenced in medical research for more than 40 years, advances over the last decade have made it increasingly relevant as an ophthalmic imaging technique suitable for daily practice. FAF provides a view of the disease processes from a metabolic perspective. Autofluorescence test for plaquenil toxicity Side effects plaquenil mayo clinic Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. The recent publication of a large demographic study has shown that toxicity is not rare among long-term users of the drug, and the risk is highly dependent on the daily dose by weight. Images of conventional A and ultra-widefield fundus autofluorescence B in a representative case of early hydroxychloroquine HCQ retinopathy showing characteristic photoreceptor defects on optical coherence tomography OCT B-scan C. C The inset shows the scanned area of OCT. Figure 1 is an image of an ocular fundus using autofluorescence to designate an area of retinal damage. To detect chloroquine toxicity. Plaquenil toxicity first affects small areas of the retina between 5° and 15° from the fovea. Figures 2 and 3 show three patients at different stages of toxicity. It has also helped us understand certain pathophysiological mechanisms. Research has shown it to be effective in the early detection of retinal disease and the potential predictive makers for progression. Images early plaquenil toxicity fundus autoflurouecense A Clinical Guide to Fundus Autofluorescence, Evaluation of Hydroxychloroquine Retinopathy Using Ultra. Plaquenil and dental implantsPlaquenil ear problemsPlaquenil sore throat Autofluorescence imaging allows for earlier diagnosis of retinal dystrophies. etc. central serous retinopathy, hydroxychloroquine toxicity, parafoveal telangiectasis and age-related macular. Autofluorescence imaging allows for earlier diagnosis of.. Retina Today - Evaluating Hydroxychloroquine Toxicity With.. FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE.. Advanced hydroxychloroquine toxicity presents as a bullseye maculopathy. Since retinal toxicity is usually irreversible, early detection of retinal toxicity and cessation of the offending agent is the best treatment. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision. Participants. Twenty-four eyes of 12 patients with definite HCQ toxicity, 31 eyes of 16 clinically normal patients at high risk of developing HCQ toxicity taking HCQ longer than 5 years, and 16 eyes of 8 clinically normal patients at low risk of developing HCQ toxicity taking HCQ fewer than 5 years, as well as 22 age-matched healthy subjects. Hydroxychloroquine Retinopathy - Correlation of Fundus Photography and Fundus Autofluorescence Imaging. These are images from a patient with hydroxychloroquine retinopathy. The fundus autofluorecence image on the right shows more evidence of retinopathy than the less sensitive fundus photograph.