Pharmacokinetics of chloroquine

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  1. Vumnik User

    Pharmacokinetics of chloroquine


    Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells.

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    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Professional guide for Chloroquine. Includes pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. The pharmacokinetic properties of chloroquine are still under debate. To establish the pharmacokinetics of a single dose of chloroquine and its metabolites, 19 healthy volunteers, including one.

    Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues.

    Pharmacokinetics of chloroquine

    Pharmacokinetics of Chloroquine and Some of Its Metabolites., Chloroquine Professional Patient Advice -

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  7. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    • Chloroquine C18H26ClN3 - PubChem.
    • Single-Dose Pharmacokinetics of Chloroquine and its Main..
    • Pharmacokinetics of Chloroquine and Some of Its..

    Chloroquine is extensively distributed with an enormous total apparent volume of distribution Vd more than 100 L/kg, and a terminal elimination half-life of 1 to 2 months. As a consequence, distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria. The use of saliva levels as an alternative to plasma levels in monitoring chloroquine therapy was studied in five healthy volunteers. Subjects took two 250mg tablets of chloroquine diphosphate 300mg chloroquine base with 200ml of water. Saliva and blood samples were collected at intervals over 6 days. Plasma was separated from blood samples after centrifugation while saliva samples were. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

     
  8. sovetttnica Moderator

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  10. agnislav Well-Known Member

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