It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine bursitis Dark spots covering face from plaquenil Side effect of plaquenil on eyes Hydroxychloroquine lysosome inhibitor Methotrexate vs plaquenil side effects long term and short term I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. In defense of your ophthalmologist, the eye problems with Plaqueni, although rare are dose related. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have other medical problems, one drug might be better for you and you should discuss this with your rheumatologist. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Interactions between plaquenil and methotrexate Hydroxychloroquine and methotrexate Drug Interactions - RxList, Plaquenil Oral Interactions with Other Medication Plaquenil for autoimmune hivesPlaquenil and benadrylChloroquine site drugs.comPlaquenil and weight loss Over the past few years, data have appeared that indicate a potential interaction between MTX and proton pump inhibitors PPIs. Evidence of an Interaction. The first case report of a potential interaction between MTX and a PPI was noted in a patient with osteosarcoma who was receiving high-dose 15 g MTX. Methotrexate and Proton Pump Inhibitors. Plaquenil vs Methotrexate Antineoplastics Cancer drugs.. Methotrexate Injection Side Effects, Dosage, Uses, and More. Combined use of methotrexate with gold, penicillamine, hydroxychloroquine, sulfasalazine, or cytotoxic agents, has not been studied and may increase the incidence of adverse effects. Rest and physiotherapy as indicated should be continued. Methotrexate is available under the following different brand names Trexall, Otrexup, and Rasuvo. Drug Interactions between methotrexate and Plaquenil. This report displays the potential drug interactions for the following 2 drugs Interactions between your drugs. Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.