Acute chloroquine poisoning

Discussion in 'Discount Prescriptions' started by XeonN, 06-Mar-2020.

  1. ivanrr Well-Known Member

    Acute chloroquine poisoning


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Acute chloroquine intoxication is responsible for a hypokalaemia which correlates with the gravity of the intoxication and may be due to a transport-dependent mechanism. Plasma potassium concentrations should be carefully observed, particularly among patients who also receive catecholamine infusions. Apr 02, 2019 Consider a 1 mmol/kg bolus of NaHCO3 prior to intubation to guard against acidemia from hypoventilation, which may worsen chloroquine toxicity. Some studies suggest that the use of thiopentone for induction is associated with cardiac arrest in cases of severe chloroquine toxicity.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Acute chloroquine poisoning

    Chloroquine - Wikipedia, Hypokalaemia related to acute chloroquine ingestion.

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  6. In the recent study two cases of the acute chloroquine poisoning, hospitalized in the Toxicology Department in Kraków, were described and one of them was fatal. The first case was 16-year-old girl who ingested 5 g of chloroquine phosphate in the suicidal attempt.

    • Acute chloroquine intoxication--rare, but always serious..
    • Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum.
    • Quinine and chloroquine - ScienceDirect.

    The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. In addition, chloroquine is prescribed as therapy for certain connective tissue disorders. Consequently, there are many opportunities for children to be poisoned through chloroquine ingestion. To alert medical practitioners and the public to this danger, the following cases of chloroquine poisoning recently reported to CDC are presented. Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss. Severity of symptoms is closely related to the ingested dose and plasma concentration. Single-dose activated charcoal can be given within 1.

     
  7. [email protected] New Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Drug and Medication User Reviews on RxList How long does hydroxychloroquine take. - St Thomas Lupus T. How long did Plaquenil/Hydroxychloroquine take.
     
  8. sumeragi-anna XenForo Moderator

    Plaquenil Oral Uses, Side Effects, Interactions. It belongs to a class of medications known as disease-modifying antirheumatic drugs DMARDs. It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known.

    Plaquenil Dosage Guide -
     
  9. Deus Guest

    Stomach upset or hydroxychloroquine? Good morning. - NRAS Hydroxychloroquine can cause an upset tum, it's a common side effect so it could be the longer you're taking it there's a build up effect. Trouble is you've other things coming up so it could be nervous tum, or even the two both making your tum particularly sensitive.

    Hydroxychloroquine Plaquenil Toxicity and Recommendations.