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    Products affected Information for consumers and caregivers Information for healthcare professionals Review Summary What actions are Medsafe taking? How to report adverse events Further information Domperidone is an anti-nausea medicine that has gastroprokinetic properties. Domperidone is used to treat: Recent research has suggested an increased risk of QT prolongation (alteration of the electrical activity of the heart), arrhythmias (unstable heartbeats) and sudden cardiac death with the use of oral domperidone. Medsafe outlined these concerns in a monitoring communication published during March 2014. Due to these concerns, Medsafe and the Medicines Adverse Reactions Committee (MARC) reviewed the benefits and risks of harms of domperidone-containing medicines. Monitoring communication: Domperidone (Motilium, Prokinex) and effects on the heart Medicines Adverse Reactions Committee minutes of the 158 meeting Medsafe and the MARC have concluded there is a small increased risk of adverse heart effects. However, the balance of benefits and potential harms for domperidone remains favourable. Motilium can be useful for treating nausea and vomiting due to many causes, including anti-cancer chemotherapy, general anaesthetics and in migraine. It can also used to prevent nausea and vomiting that may be caused by medicines for Parkinson's disease, such as levodopa, pramipexole and apomorphine. Motilium tablets contain the active ingredient domperidone, which is a type of medicine called a dopamine antagonist. Domperidone works primarily by blocking dopamine receptors found in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and so prevents reflux (regurgitation of the stomach contents back into the foodpipe). Domperidone also blocks dopamine receptors found in an area of the brain known as the chemoreceptor trigger zone (CTZ).

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    I am a consultant specializing in the selection of HR & payroll software for a range of clients in many sectors in various countries, primarily UK, Europe and the USA. I came into HR for a background in Finance, and this analytical training has stood me in good stead. A few years after, I was asked to computerize the payroll, which was manual at the time, which, having successfully been accomplished, the next step was to find an HR system for the personnel records. The rest is history, as ever since then people have asked me to do things because I “knew about that stuff” and the whole arena of HR & payroll systems was an area of considerable trepidation for HR & payroll professionals, and Information Technology had very much occupied that space by default at the time. My philosophy has always been to act as an enabler with clients, lighting the way for them to arrive at the most suitable conclusions; that way, the client has ownership, and the knowledge stays with them rather than passing through the door after the project. After co-founding the niche HRmeansbusiness consultancy in 2000, I went on to build and launch the HRcomparison website (for comparison of HR, Payroll and Time & Attendance software), that was the first of its kind in the UK and currently features over 60 vendors. Currently I am working on a series of webinars and seminars for 2015 on HRIS topics and a book is already under way. Domperidone belongs to the group of medications called dopamine antagonists. It is used to treat slowed movement in the gastrointestinal tract associated with diabetes and gastritis (inflammation of the stomach lining). For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness. Domperidone is also used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson's disease. It works to improve symptoms by helping the stomach to empty more quickly and to reduce nausea. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.

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