I read that the sulfa in Plaquenil is different from those in antibiotics and most people with Lupus have an allergy to Sulfa but can take Plaquenil without any problems. I can say, however, that I have not had any cross allergic reaction to other drugs sometimes associated with sulfa allergies. Whether you try Plaquenil or not is ultimately up to you and your doctor, but a lot will depend on the type and severity of reactions that you've had. Chloroquine malaria mechanism of action Plaquenil discontinued Eye report for hydroxychloroquine Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Oct 21, 2015 These are not sulfates. Sulfate used after a drug name is just the last name of the chemical, its the sulfate salt. It has nothing to do with sulfonamides. Allergy to sulfonamide antibiotics has no relationship to allergies to hydroxychloroquine. Sep 02, 2009 I have been allergic to sulfa meds for over 30 years. I have been taking plaquenil for about 8 years with no problems. However, I was givin the generic Plaquenil at first, and I did have a reaction to that - until now I didn't reliese was the same as my sulfa reaction. My reaction to sulfa consisted of wheezing, but no major distress, and Plaquenil was sufficiently different from Gantrisin that my doctor felt comfortable with prescribing it. Rashes are certainly a lot less severe than respiratory reactions. Plaquenil sulfa drug Plaquenil and Sulfa Allergies" Lupus Community - Support., Is hydroxychloroquine Sulfate a member of the sulfa drug family? Is plaquenil still the go drug for lupudHydroxyzine chloroquine Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Hydroxychloroquine - Wikipedia. If you are allergic to sulfa drugs does this mean you can't.. Bactrim and Plaquenil drug interactions - eHealthMe. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Someone who has a sulfa allergy can react to some medications that contain sulfa. Sulfonamide antibiotics that can cause a reaction. Antibiotics containing chemicals called sulfonamides can trigger a reaction if you have a sulfa allergy. These antibiotics include combination drugs The drugs will carry a "black box" warning about these risks. DMARDs slow down rheumatoid arthritis and improve quality of life for most people. Some will even achieve a remission while taking them.