I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil withdrawal symptoms Plaquenil interaction with alcohol Choi et al 2014 chloroquine paclitaxel Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. PREGNANCY AND LACTATION. Hydroxychloroquine is considered safe in all trimesters of pregnancy. Due to the high risk of flare in systemic lupus erythematosus when discontinuing this medication, continued Plaquenil use is advised in these patients during pregnancy. Small amounts of hydroxychloroquine can be found in breastmilk. Hydroxychloroquine sulfate Plaquenil is not a sulfa drug. That is a misconception. However, hydroxychloroquine can be associated with serious dermatological side effects including severe rashes and exacerbation of psoriasis. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Plaquenil and sulfasalazine Hydroxychloroquine Uses, Dosage & Side Effects -, Hydroxychloroquine Plaquenil RheumTutor Can plaquenil cause visual fieldHydroxychloroquine tablets ip 200 mg uses Hey everyone! Is anyone here with psoriatic arthritis just taking plaquenil or sulfasalazine or both together? I’m curious to know if these drugs can individually or mutually be enough to control inflammatory symptoms. Any success with plaquenil or sulfasalazine? PsoriaticArthritis. Plaquenil and Sulfa Allergies" Lupus Community - Support Group. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Plaquenil is an antimalarial medication and Azulfidine EN-tabs is an anti-inflammatory agent and immunomodulatory agent. Side effects of Plaquenil and Azulfidine that are similar include nausea, vomiting, loss of appetite, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, or itching or skin rash.