I would appreciate feedback on the reasoning outlined below. I have convinced myself that it makes sense, but am looking for independent feedback and have been struggling to get it. Plaquenil and blood glucose Plaquenil fda package insert Mechanism of action/Effect Antiprotozoal—Malaria Unknown, but may be based on ability of hydroxychloroquine to bind to and alter the properties of DNA. Also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. TreatmentResearchPharmacologySymptomsRisksInteractionsAdministrationResults , etc.), or provide argument why this is a dumb idea. I would greatly appreciate it if someone could knit-pick this with a fine tooth comb and try and find some mistake I've made (off by a order of magnitude? Mechanism of action hydroxychloroquine Mechanisms of Action of Hydroxychloroquine in Reducing Risk., Chloroquine - Wikipedia Plaquenil testsHydroxychloroquine dmardHydroxychloroquine and notalgia paresthetica Mechanisms of action Various modes of action are postulated to explain the therapeutic and/or adverse effects of hydroxychloroquine and chloroquine, most of which have been based on in vitro. Mechanisms of action of hydroxychloroquine and chloroquine.. Hydroxychloroquine Plaquenil -. Chloroquine analogues in drug discovery new directions of.. Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. A wide variety of mechanisms of antirheumatic action have been proposed for chloroquine and hydroxychloroquine, but any model must account for a the slow onset of action usually 8 to 12 weeks, in contrast to the rapid onset of therapeutic benefit after administration of salicylates, corticosteroids, or nonsteroidal anti-inflammatory drugs; b. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral.