Mechanism of action hydroxychloroquine

Discussion in 'Chloroquine Without A Doctors Prescription' started by semenov, 09-Mar-2020.

  1. Phoenix168 XenForo Moderator

    Mechanism of action hydroxychloroquine


    I would appreciate feedback on the reasoning outlined below. I have convinced myself that it makes sense, but am looking for independent feedback and have been struggling to get it.

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    Mechanism of action/Effect Antiprotozoal—Malaria Unknown, but may be based on ability of hydroxychloroquine to bind to and alter the properties of DNA. Also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. TreatmentResearchPharmacologySymptomsRisksInteractionsAdministrationResults

    , etc.), or provide argument why this is a dumb idea. I would greatly appreciate it if someone could knit-pick this with a fine tooth comb and try and find some mistake I've made (off by a order of magnitude?

    Mechanism of action hydroxychloroquine

    Mechanisms of Action of Hydroxychloroquine in Reducing Risk., Chloroquine - Wikipedia

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  5. Mechanisms of action Various modes of action are postulated to explain the therapeutic and/or adverse effects of hydroxychloroquine and chloroquine, most of which have been based on in vitro.

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    Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. A wide variety of mechanisms of antirheumatic action have been proposed for chloroquine and hydroxychloroquine, but any model must account for a the slow onset of action usually 8 to 12 weeks, in contrast to the rapid onset of therapeutic benefit after administration of salicylates, corticosteroids, or nonsteroidal anti-inflammatory drugs; b. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral.

     
  6. Ven. Guest

    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Plaquenil Oral Interactions with Other Medication DRUGS THAT SUPPRESS TSH OR CAUSE. - PubMed Central PMC Will you have Hypothyroidism with Plaquenil - eHealthMe
     
  7. vipasus Well-Known Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Breaking pills in half hydrochloroquine/plaquinil? - LUPUS UK Bone Joint Muscle - Arthritis Is anyone taking liquid. Plaquenil Withdrawal – Life As An Anomaly
     
  8. akristina User

    Buy Plaquenil Online - Universal Drugstore™ What is a generic medication? Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication.

    Hydroxychloroquine Uses, Dosage & Side Effects -
     
  9. bytag User

    Plaquenil hydroxychloroquine Basics, Side Effects & Reviews. Plaquenil hydroxychloroquine has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil hydroxychloroquine is commonly used for lupus in children because of less side effects compared to other medications. Plaquenil hydroxychloroquine helps minimize joint damage.

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