Hydroxychloroquine retinal toxicity risk factors

Discussion in 'Chloroquine 250' started by linchese, 22-Feb-2020.

  1. FriendBot New Member

    Hydroxychloroquine retinal toxicity risk factors


    Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid).

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    Additionally, patients who already have retinal and macular disease may masquerade or be subclinical simply because it can be very difficult to follow these patients with current testing strategies. 5 It is prudent to take notice of these additional risk factors carefully when screening patients. Sep 15, 2014 Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Because it presents potential secondary effects including irreversible maculopathy, knowledge of incidence, risk factors, drug toxicity and protocol screening of the patients it represents important data for the ophthalmologists. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs.

    It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015.

    Hydroxychloroquine retinal toxicity risk factors

    Retinal Toxicity in Patients Treated With Hydroxychloroquine., Retinal toxicity associated with chronic exposure to.

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  6. Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull’s eye maculopathy. The risk may be much higher because retinopathy can be detected earlier when using more sensitive screening.

    • Toxic Retinopathy With Hydroxychloroquine Therapy.
    • My Take on New Ocular Screening Guidelines for Plaquenil RheumNow..
    • Despite Plaquenil dosing recommendations, retinal toxicity remains.

    Hydroxychloroquine has a lower risk of ocular toxicity, both corneal and retinal, compared with chloroquine. Smoking possibly reduces the efficacy of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Other risk factors for Hydroxychloroquine retinal toxicity include kidney or liver disease and obesity. Obesity is a risk factor because the drug does not penetrate fat tissue so there is more of the drug in your lean body mass including your retina and its supporting cells called the retinal pigment epithelium. Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull’s eye maculopathy.

     
  7. maxwell_c XenForo Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Caution! These 10 Drugs Can Cause Memory Loss - AARP Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  8. mgn New Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine C18H26ClN3 - PubChem Chloroquine method Sanctioned Suicide
     
  9. Manderlay User

    How effective is Plaquenil for Mixed connective tissue. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Mixed connective tissue disease and for what kind of people. The study is created by eHealthMe from 35 Plaquenil users and is updated continuously.

    Mixed Connective Tissue Disease MCTD - NORD National.