Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine Does plaquenil help raynaud's Oct 01, 2018 Chloroquine - Clinical Pharmacology Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Pharmacology. Mechanism of Action Immune modulator. Chloroquine, an alkylated 4-aminoquinoline and analog of hydroxychloroquine, is an FDA-approved drug indicated for the treatment of malaria and extraintestinal amebiasis. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Pharmacology of chloroquine Chloroquine Pharmacology & Usage Details Medicine India, Chloroquine Information for Providers AIDSinfo Plaquenil and epidural anesthesia Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate. It also can be given by intramuscular injection as chloroquine hydrochloride. Chloroquine drug Britannica. Hydroxychloroquine DermNet NZ. CHLOROQUINE PHOSPHATE, USP. Pharmacology Indication Chloroquine is indicated to treat infections of P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. 18 It is also used to treat extraintestinal amebiasis. 18 Resistance of Plasmodium parasites to chloroquine is widespread see INDICATIONS AND USAGE – Malaria. Patients in whom chloroquine or hydroxychloroquine have failed to prevent or cure clinical. In the treatment of diseases other than malaria, chloroquine is administered in a much larger dosage and more frequently, usually 250 to 750 mg daily. 1 The occurrence of a characteristic retinopathy following the long-term daily ad- ministration of chloroquine has now been well documented. 2 The fact that the retinal lesion usually develops after one or more years of drug ingestion, plus the remarkably large accumulation of chloroquine in body tissues and organs, 3-5 suggests that the.