Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Discontinuing plaquenil now have muscle spasms How to take plaquenil Jan 15, 2020 Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram Dec 15, 2017 7 health conditions that can cause hyperpigmentation. One of the commonest manifestations of hormonal imbalance on the skin is melasma or dark brown spots on the skin. In. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more Dr. Krauser on melasma and lupus Malignant melanoma is a malignant skin cancer that can metastasize. It is seen in pigmented skin lesions. Lupus is an abnormal body response that forms antibodies that can harm vital organs and skin. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil cause melasma Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Health conditions that can cause hyperpigmentation. Otezla and plaquenilPlaquenil liver failureChloroquine how does it work Re Could Melasma be Lupus Related Hi. If I were in your shoes, I'd see a new rheumie affiliated with a teaching hospital, the theory being that teaching hosp. doctors are much more likely to see more variants of lupus/similar conditions. Immune & Autoimmune - Lupus Could Melasma be Lupus Related. Melasma and lupus - Things You Didn’t Know. Skin Discoloration and Plaquenil - Arthritis Information. Mar 16, 2011 I have been on it for 8 months straight this time joint pain has improved. I now have hyperpigmentation a darkening or tanned effect on my face and forearms that showed up several months ago and it looks similar to Melasma, I have researched and found this is a side effect of plaquenil. I have have been on plaquenil for over a year. It's really made my RA manageable, however, Plaquenil is an anti-malarial and pretty well known for its possible skin discoloration side effects. As you can guess from the title, I now have a beautiful melasma mustache and melasma across my cheeks and forehead. It's great. Melasma is common and annoying and often chronic skin condition. It is more common in people with darker skin types, and those who have extensive sun exposure. It is particularly common when a woman becomes pregnant "the mask of pregnancy", and less so when taking the birth control pill. I'm not aware of plaquenil as a cause for melasma.