If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Plaquenil and mctd Icd 10 screening on plaquenil Plaquenil mechanism of action in lupus Chloroquine prescription For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Methotrexate and Sjogren syndrome - from FDA reports Summary Sjogren syndrome is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Dizziness. Does anyone use methotrexate just for their Sjogrens symptoms? If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. Sjogren's Syndrome Support. Methotrexate opinions. Symptoms and Medical Treatments _Lisa_D. I used plaquenil for some. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Sjogren's Syndrome Methotrexate, Will you have Sjogren syndrome with Methotrexate - eHealthMe Can i take plaquenil with methocarbamol Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Ask the Expert Plaquenil and Sjögren’s. Methotrexate opinions - Symptoms and Medical Treatments.. Plaquenil for treating Sjogren's Syndrome Treato. Dec 28, 2017 Methotrexate vs. Plaquenil - Autoimmune diseases. and thinks I should try Methotrexate. listed as one of the symptoms of Sjogren's Syndrome, but I was. Plaquenil hydroxychloroquine "I have been on this medication for approximately 8 years. Before I started this medicine I was in terrible shape. With Sjogren's syndrome as my primary autoimmune disease and rheumatoid arthritis as my secondary autoimmune disease I was in terrible persistent pain. Plaquenil or Methotrexate? Support Forums Sjogren's Syndrome. And, Plaquenil takes 2-3 months to build up in your system. So in the event that you are one of the people who is actually able to notice a difference in symptoms, you may not notice them for 2-3 months.