If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Contact us if you experience any difficulty logging in. Plaquenil and parasites Plaquenil and iron Overview of Hyper- and Hypopigmentaion in Scleroderma. Systemic sclerosis SSc such as limited or diffuse scleroderma, can cause hyperpigmentation darkening and hypopigmention lightening of the skin, usually in the areas which have been affected by skin hardening. Hyperpigmentation due to hydroxychloroquine for lupus? My relative has hyperpigmentation on her face from using hydroxychloroquine for her lupus. She's really self conscious about it and is looking for a solution. Skin pigmentation related to antimalarials is described as yellow brown to slate gray or black pigmentation, which predominates on the anterior side of the shins but can also be seen in the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. 16 This is consistent with our findings because all patients had skin. In many cases, once the offending drug has been stopped, fading of the lesions occurs. Drug-induced skin pigmentation can become cosmetically disfiguring. Hyperpigmentation of the skin due to hydroxychloroquine Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one., Hyperpigmentation due to hydroxychloroquine for lupus. Ibuprofin and plaquenilPlaquenil for atopic dermatitisCan i take omeprazole with hydroxychloroquine The risk of hydroxychloroquine-related retinopathy associated with skin hyperpigmentation is unknown.3 The risk of eye toxicity increases sharply toward 1% after five to seven years of hydroxychloroquine use, or a cumulative dose of 1000 g.4 Hydroxychloroquine-related skin discoloration CMAJ. Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus.. Hydroxychloroquine-Induced Hyperpigmentation JCR Journal of Clinical.. A skin biopsy of the patient's dyschromia confirmed the diagnosis of hydroxychloroquine-associated hyperpigmentation. Hyperpigmentation of skin, mucosa, and nails can be observed in patients. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. The skin discoloration can develop after one year of hydroxychloroquine treatment. The hyperpigmentation may start to fade out a few months after the cessation of the drug. Few case reports found that laser therapy is useful in treating patients with hydroxychloroquine induced hyperpigmentation.