Metformin byetta

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  1. Gorodetskiy Guest

    Metformin byetta


    Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) medication, belonging to the group of incretin mimetics, approved in April 2005 for the treatment of diabetes mellitus type 2. Exenatide in its Byetta form is administered as a subcutaneous injection (under the skin) of the abdomen, thigh, or arm, any time within the 60 minutes before the first and last meal of the day. The medication is injected subcutaneously twice per day using a filled pen-like device (Byetta), or on a weekly basis with either a pen-like device or conventional syringe (Bydureon). The main side effects of exenatide use are gastrointestinal in nature, including acid or sour stomach, belching, diarrhea, heartburn, indigestion, nausea, and vomiting; exenatide is therefore not meant for people with severe gastrointestinal disease. Other side effects include dizziness, headache, and feeling jittery. Drug interactions listed on the package insert include delayed or reduced concentrations of lovastatin, paracetamol (acetaminophen), and digoxin, although this has not been proven to alter the effectiveness of these other medications. In response to postmarketing reports of acute pancreatitis in patients using exenatide, the FDA added a warning to the labeling of Byetta in 2007. In August 2008, four additional deaths from pancreatitis in users of exenatide were reported to the FDA; while no definite relationship had been established, the FDA was reportedly considering additional changes to the drug's labeling. In deze rubriek worden geneesmiddelen besproken, kort nadat ze in de handel zijn gebracht, of als er sprake is van een uitbreiding van de indicatie. De plaatsbepaling kan meestal slechts voorlopig zijn, omdat nog relatief weinig bekend is over de veiligheid en effectiviteit. Wanneer nieuwe gegevens daartoe aanleiding geven, komen wij op de eerste bespreking terug. De pictogrammen betekenen: : een belangrijke uitbreiding van het farmacotherapeutische arsenaal, : een nuttig geneesmiddel, -: een middel met twijfelachtig nut, of een middel waarvan de waarde nog niet goed kan worden beoordeeld, -: een middel zonder toegevoegde waarde, --: een middel met extra risico's dat niets toevoegt aan de behandelmogelijkheden. De prijzen zijn berekend aan de hand van de G-Standaard van de Z-Index van maart 2008, vergoedingsprijzen excl. Pilwaardering: /- Exenatide Byetta® (Eli Lilly Nederland)oplossing voor injectie 0,25 mg/mlbehandeling diabetes mellitus type 2 Exenatide (Byetta®) is geregistreerd voor de 'behandeling van diabetes mellitus type 2 in combinatie met metformine en/of een sulfonylureumderivaat, indien met maximaal verdraagbare doseringen van deze orale middelen geen adequate glykemische controle wordt bereikt'.1 Exenatide behoort tot een nieuwe klasse van geneesmiddelen, de incretine-mimetica. Het middel heeft een antihyperglykemische werking die vergelijkbaar is met het lichaamseigen glucagonachtige peptide-1 (GLP-1). Doordat exenatide vermoedelijk de GLP-1-receptor activeert, wordt de secretie van insuline door de pancreas gestimuleerd.

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    Indications and Usage For ByettaByetta Dosage and AdministrationDosage Forms and StrengthsContraindicationsWarnings and PrecautionsAdverse ReactionsDrug InteractionsUse in Specific PopulationsOverdosageByetta DescriptionByetta - Clinical PharmacologyNonclinical ToxicologyClinical StudiesHow Supplied/Storage and HandlingPatient Counseling InformationByetta 5 Mcg Representative PackagingByetta 10 Mcg Representative Packaging Medical use. Exenatide is used to treat type 2 diabetes mellitus as an add-on to metformin, a biguanide, or a combination of metformin and a sulfonylurea. BYETTA comparison study with insulin lispro mealtime insulin A 30-week trial compared the addition of BYETTA twice daily with insulin lispro mealtime insulin three times daily in adult patients with type 2 diabetes uncontrolled on a background of basal long-acting insulin glargine and metformin.

    There's a class of type 2 diabetes drugs called incretin mimetics or glucagon-like peptide 1 (GLP-1) agonists that are taken by injection, but aren't insulin. These medications not only improve blood sugar control but may also lead to weight loss. Depending on the medication and the dose, weight loss may average about 3 to 5.5 pounds (1.5 kilograms, or kg, to 2.5 kg) when using these drugs. If you're actively trying to lose weight through lifestyle changes and the use of one of these medications, research has shown that the drugs may lead to around 6 to 9 pounds (2.8 kg to 4.2 kg) of additional weight loss. These medications improve blood sugar control by mimicking the action of a hormone called glucagon-like peptide 1 (GLP-1). Among other things, these drugs stimulate insulin secretion in response to rising blood sugar levels after a meal, which results in lowering of the blood sugar. There are many proposed ways in which these medications cause weight loss. But the most prominent effect of these drugs is that they delay the movement of food from the stomach into the small intestine. This is a summary of the European public assessment report (EPAR) for Byetta. It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Byetta. It is used together with other antidiabetes medicines in patients whose blood glucose (sugar) levels are not adequately controlled with the maximum tolerated doses of the other medicines. It can be used with metformin, sulphonylureas, thiazolidinediones, metformin and a sulphonylurea, or metformin and a thiazolidinedione. Byetta can also be given to patients taking basal insulin (long-acting insulin such as insulin glargine) with or without metformin and / or pioglitazone (a thiazolidinedione) and whose blood glucose levels are not adequately controlled with these medicines. The medicine can only be obtained with a prescription. Byetta is given by injection under the skin of the thigh, the abdomen (tummy) or the upper arm, using the injection pen. Treatment with Byetta should start at a dose of 5 micrograms twice a day for at least a month. The dose can then be increased to 10 micrograms twice a day.

    Metformin byetta

    Byetta for Weight Loss - Diabetes Home Page, Exenatide - Wikipedia

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  7. Two further studies compared adding Byetta or an insulin to metformin and sulphonylureas. In one study.

    • Byetta European Medicines Agency.
    • BYETTA vs Rapid Acting Insulin - Type 2 Diabetes Medication.
    • GLP-1 agonists Diabetes drugs and weight loss - Mayo Clinic.

    Byetta has been studied as monotherapy and in combination with metformin, a sulfonylurea, a thiazolidinedione, a combination of metformin and a sulfonylurea, a combination of metformin and a thiazolidinedione, or in combination with insulin glargine with or without metformin and/or thiazolidinedione. Byetta 26 ervaringen met effect en bijwerkingen. Man, 59 Ik gebruik nu 6 maanden Byetta in het begin misselijk maar gaat moet je 6 uur tussen. Exenatide Byetta® is geregistreerd voor de 'behandeling van diabetes mellitus type 2 in combinatie met metformine en/of een sulfonylureumderivaat.

     
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