Chloroquine working concentration

Discussion in 'Canadian Drugs' started by natabalota, 05-Mar-2020.

  1. Chloroquine working concentration


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Oct 01, 2018 Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver,spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma. Chloroquine has antiviral effects, which work by increasing endosomal pH resulting in impaired virus/cell fusion that requires a low pH. 32 33 Chloroquine also seems to act as a zinc ionophore, thereby allowing extra cellular zinc to enter inside the cell and inhibit viral RNA dependant RNA polymerase. Peak plasma concentration is reached 1.5 to 3 hours after ingestion. Distribution by route of exposure Protein binding 5O to 65%. Chloroquine accumulates in high concentrations in kidney, liver, lung and spleen, and is strongly bound in melanin-containing cells eye and skin. Red cell concentration is five to ten times the plasma concentration.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine working concentration

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  7. Peak concentration after the first dose of chloroquine ranged between 9 and 62 ng/ml. Desethylchloroquine was also slowly cleared from plasma and mean concentration at the end of 7 days was 49% of the mean concentration at the end of 3 days.

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    The extracts were preincubated for 1 hr in PBS, pH 7.2, at 37 in the presence or absence of chloroquine 1 mM in experiment 1; 2mM in experment 2, washed several times with buffer and then assayed for heme polymerase activity as described Slater and Cerami, 1992. Other samples were preincubated in buffer. The time-honoured oral chloroquine regimen of 25 mg base/kg spread over 3 days 10, 10, 5 or 10, 5, 5, 5 mg/kg at 24-hour intervals can be condensed into 36 hours of drug administration. There is no role today for parenteral chloroquine. Chloroquine is considered safe in pregnancy and in young children. Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt.

     
  8. vibre Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Taking Plaquenil for Rheumatoid Arthritis How Does Plaquenil Work For Rheumatoid Arthritis Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
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    Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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