Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine and infertility Lyrica and plaquenil Have been taking Plaquenil for over a year now and it has definitely made a huge difference in my quality of life. When I first went to my Rhuemy and found out what was wrong, I was so sick I could barely function with fatigue, joint and muscle aches just to name a few. 8 replies I have been taking Plaquenil 400 mg per day for about 2 years now due to lupus flare. When i first started it, I was also started on prednisone to get my inflammation under control. Actually I started on 200 mg per day and about 2 months before tapering off pred, he upped me to 400 mg per day of plaquenil to give it plenty of time to kick in. Apr 10, 2019 Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area. To treat malaria Plaquenil is usually given for 3 days. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Taking plaquenil over 2 years Protecting your eyesight when taking Plaquenil Lupus., Plaquenil - Malaria prophylaxis chloroquine doseHydroxychloroquine ocular side effects For Systemic Lupus Erythematosus "Several years ago took Plaquenil for over two years, took about 6 months before it was effective. I have now restarted again this time it has become effective in about 10 weeks, no measurable side effects and less pain." Plaquenil Reviews & Ratings at. Plaquenil Uses, Dosage & Side Effects -. Plaquenil & Weight Gain/Loss -. I have also been on Plaquenil for about 2 1/2 years. I have Lupus and Sjogrens. I have had a bad flare for about 3 months, doing some better now, but I also wondered if I wasn't back sliding. I felt so much better for a little over 2 years. I hurt so bad and am so tired and weak. I have to force myself to get anything done. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Within 2 months of taking Plaquenil the pain and fatigue had subsided, not completely but has greatly improved over the last year and half & my health and immune system has also improved and I went from being sick ALL the time to very rarely sick. It has been a Godsend for me.