I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Plaquenil and radiation Chloroquin Long term use of plaquenil and surgery Jan 27, 2010 The only thing I can think is that when you stop the plaquenil quickly one might have a flare that occurs "slam bam". If you taper off the flare may come anyway but maybe it would be slower and more mild. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; very slow heart rate, weak pulse; I was told I didn't have to taper it like prednisone, and that I shouldn't expect any rebound type of reaction like you get when your body adjusts to being off pred. But everyone is taking a different mix of drugs and maybe you're taking something I don't that would make your doctor's recommendation for you different. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Ddo you have to stop plaquenil slowly Treatment/Plaquenil -, Plaquenil Uses, Dosage & Side Effects - Chloroquine usesHydroxychloroquine neuropathyPlaquenil and sun sensitivityHow much plaquenil medication costPlaquenil eye irregularity YES.stopping plaquenil for a couple of days can cause symptoms to arise or get worse.needs to be taken exactly as prescribed. Twice a day, every day. Missing one dose wont make a major difference but skipping more then one, or days absolutely can. It happened to me when I ran out of it and waited to get my refil. Will never do that again. Stopping plaquenil. DailyStrength. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. Stopping Methotrexate - Arthritis Information. Though Plaquenil is generally regarded as safe during pregnancy, it is recommended that effective birth control is used throughout the course of Plaquenil treatment and for up to six months after treatment is stopped. However, I do have Sjögren's Syndrome, as well as PMR, and it's supposed to help with that. Again, I'm not convinced the HCQ does help, but I suppose the only way for me to find out is to stop taking it! As others have said, for you to be on 5mg of Pred. after only 15 months, seems to be good going. As a result, all patients taking plaquenil should have an examination approximately every six months. The macula should be examined through a dilated pupil. The incidence of Plaquenil related macular problems increases when approaching a dose of 600 to 700 mg. per day. The average dose is 400 mg. per day. This is a very safe dose.