Why malaria becomes resistant to chloroquine

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    Why malaria becomes resistant to chloroquine


    Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against malaria. Although these treatments are working well in many parts of the world, there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.

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    Information regarding the geographic areas where resistance to Chloroquine occurs, is available at the Centers for Disease Control and Prevention gov\malaria. Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.

    The cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. As the threat of antimalarial drug resistance grows, there is increasing pressure to sustain the efficacy of existing treatments, develop alternative treatments, as well putting in place preventative measures such as bednets.

    Why malaria becomes resistant to chloroquine

    Chloroquine MedlinePlus Drug Information, Aralen chloroquine Malaria Drug Side Effects & Dosage

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  4. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine is used to treat and to prevent malaria.

    • Chloroquine Uses, Side Effects & Warnings -.
    • Chloroquine Resistance in Plasmodium falciparum Malaria..
    • Chloroquine - an overview ScienceDirect Topics.

    Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

     
  5. Eamon New Member

    Suppression: 400 mg (310 mg base) orally on the same day every week Comments: -Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart). Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Lichen Planopilaris Retrospective Study and Stepwise. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
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    RheumNow Hydroxychloroquine Blood Levels in SLE MedPage Today Rheumatology General Rheumatology RheumNow Hydroxychloroquine Blood Levels in SLE — Guidelines on dosing this drug can be confusing. by Michelle Petri MD, MPH, and Laura Durcan, MD April 3, 2016

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