Chloroquine intercalation

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  1. Palpatine Guest

    Chloroquine intercalation


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    We have shown that, at given small concentrations, intercalation of chloroquine strongly facilitates the comet tail formation. At the same time, some part of DNA about 8 % in the nucleoids exits very fast independently on chloroquine, while the largest part of DNA about three quarters does not exit at all. Chloroquine. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malarial infections. It is also the cheapest, time tested and safe anti malarial agent. Mechanism of action The mechanism of action of chloroquine is unclear. Being alkaline, the drug reaches high concentration within the food vacuoles of the. Apr 02, 2019 Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine intercalation

    DNA Interaction and Dual Topoisomerase I and II Inhibition., Antimalarial Drugs – Malaria Site

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  7. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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    Another convincing argument that chloroquine acts by intercalation was made by O'Brien and Hahn6. These authors made models of chloroquine and DNA the old-fashioned hand-made type, and proposed that chloroquine bound to DNA in two ways Fig. 2. First, the aromatic quinotine rings stacked between adjacent base pairs like other intercalators. It has been suggested that chloroquine may augment oxidative stress induced by radiotherapy in the treatment of GBM. 6 The other main actions of chloroquine responsible for most intracellular actions are 1 molecular intercalation of chloroquine into DNA and 2 inhibition of lysosomic enzymes, particularly phospholipase A2. Effects of chloroquine on the torsional dynamics and rigidities of linear and supercoiled DNAs at low ionic strength. Biopolymers 1989, 28 10, 1695-1703. DOI 10.1002/bip.360281005. J. Michael Schurr, Bryant S. Fujimoto, Pengguang Wu, Lu Song.

     
  8. anka_marketanka New Member

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Prophylactic use of antimalarials during pregnancy Chloroquine - FDA prescribing information, side effects and uses Yellow Fever Vaccine & Malaria Prophylaxis Information, by.
     
  9. nikakoi New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Oral Uses, Side Effects, Interactions. Quinine Uses, Actions, & Side Effects Britannica Chloroquine Uses, Side Effects & Warnings -
     
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  11. max9 Moderator

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