It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil and bursitis Manufacturers of plaquenil Drug hydroxychloroquine oral-tablet 200mg Plaquenil bone marrow depression Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Bleeding, confusion, unusual thoughts or behavior, or; seizures convulsions. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine bleeding Drug-Induced Bleeding, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine and early pregnancyQuinacrine chloroquine antimalarial alkaloidRetinal damage plaquenilChloroquine side effects versus mefloquinePlaquenil retinopathy info for patient rheumatol Unusual bleeding or bruising unusual facial expressions unusual tiredness or weakness yellow eyes or skin Symptoms of overdose. Drowsiness dry mouth increased thirst loss of appetite mood changes no pulse or blood pressure numbness or tingling in the hands, feet, or lips unconsciousness Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. View detailed reports from patients taking plaquenil who experienced vaginal haemorrhage. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. You should also ask about taking Plaquenil in addition to Lovenox as that is the latest treatment for APS. Plaquenil is a pill, taken twice a day. I am not sure.you get into a serious car accident or something like that, then you may have an increased risk of bleeding, but I don't think the risk is very high for normal day to day life.