Valtrex mechanism of action

Discussion in 'Canada Drugs' started by rocer, 08-Sep-2019.

  1. andrey2505 Guest

    Valtrex mechanism of action


    Valtrex (valaciclovir, valacyclovir) is a kind of antiviral drug, which is intended to treat disorders caused by herpes viruses. Particularly, it is also widely used for the treatment of cold sores (oral herpes), shingles (herpes zoster) and genital herpes (herpes B.) Also, it is used to get rid of chickenpox in children over 2 years old. It should be noted that this drug alleviates symptoms, but does not treat the virus itself. After absorption from the intestinal tract, generic valacyclovir is converted to acyclovir triphosphate and amino acid valine (in the liver). Acyclovir triphosphate inhibits replication of viral DNA polymerase, as it invades the viral DNA chain and upsets the DNA strand. After that, the virus loses much of its potential and can no longer do any visible damage to the human body. Even if you do understand the drug’s mechanism of action, pharmacokinetics, pharmacodynamics, and realize the possibility of side effects, do not use it without consulting your doctor. Once you have the first symptoms characteristic of a herpes virus, call your doctor. Valtrex has been approved as a treatment for recurrent genital herpes (herpes simplex) in otherwise healthy (immunocompetent) adults. The efficacy of Valtrex has not been established in immunocompromised subjects. In clinical trials, Valtrex shortened the healing time of genital herpes sores by 33% on average compared to placebo. The duration of pain associated with genital herpes was reduced by 25% in subjects who received Valtrex as opposed to placebo. Valtrex also stopped viral shedding 50% faster on average than placebo. Viral shedding is the process in which virus is released from the skin during an outbreak of genital herpes. Valtrex has been shown to be effective when administered within 24 hours of the first sign or symptom of a recurrent genital herpes outbreak.

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    Valtrex valacyclovir HCl Treatment for recurrent genital herpes. New approved drug details including. Mechanism of Action. Valtrex is rapidly and extensively. VALTREX is a registered trademark of Glaxo Group Limited, used under. Patients should be informed that VALTREX. Mechanism of Action. Valtrex mechanism of action. Common Questions and Answers about Valtrex mechanism of action. valtrex. I am David aged 55 and employed as a postman/driver/sorter, well.

    Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to Acyclovir. It is marketed by Glaxo Smith Kline under the trade name Valtrex or Zelitrex. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism.

    Valtrex mechanism of action

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  3. Mechanism of action. Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182.

    • Valaciclovir - Wikipedia.
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    • Valtrex valacyclovir hydrochloride dose, indications, adverse..

    Mechanism of Action Valacyclovir is a nucleoside analogue DNA polymerase inhibitor. Valacyclovir hydrochloride is rapidly converted to acyclovir which has demonstrated antiviral activity against HSV types 1 HSV─1 and 2 HSV─2 and VZV both in cell culture and in vivo. Mechanism of Antiviral Action Valacyclovir hydrochloride is rapidly converted to. VALTREX and a 350-mg intravenous acyclovir dose to 12 healthy volunteers. Learn about Valtrex Valacyclovir Hydrochloride may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling. Mechanism Of Action.

     
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