Valtrex mechanism of action

Discussion in 'Canada Drugs' started by inquis, 08-Sep-2019.

  1. seotonic New Member

    Valtrex mechanism of action


    Valtrex (valaciclovir, valacyclovir) is a kind of antiviral drug, which is intended to treat disorders caused by herpes viruses. Particularly, it is also widely used for the treatment of cold sores (oral herpes), shingles (herpes zoster) and genital herpes (herpes B.) Also, it is used to get rid of chickenpox in children over 2 years old. It should be noted that this drug alleviates symptoms, but does not treat the virus itself. After absorption from the intestinal tract, generic valacyclovir is converted to acyclovir triphosphate and amino acid valine (in the liver). Acyclovir triphosphate inhibits replication of viral DNA polymerase, as it invades the viral DNA chain and upsets the DNA strand. After that, the virus loses much of its potential and can no longer do any visible damage to the human body. Even if you do understand the drug’s mechanism of action, pharmacokinetics, pharmacodynamics, and realize the possibility of side effects, do not use it without consulting your doctor. Once you have the first symptoms characteristic of a herpes virus, call your doctor. Valtrex has been approved as a treatment for recurrent genital herpes (herpes simplex) in otherwise healthy (immunocompetent) adults. The efficacy of Valtrex has not been established in immunocompromised subjects. In clinical trials, Valtrex shortened the healing time of genital herpes sores by 33% on average compared to placebo. The duration of pain associated with genital herpes was reduced by 25% in subjects who received Valtrex as opposed to placebo. Valtrex also stopped viral shedding 50% faster on average than placebo. Viral shedding is the process in which virus is released from the skin during an outbreak of genital herpes. Valtrex has been shown to be effective when administered within 24 hours of the first sign or symptom of a recurrent genital herpes outbreak.

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    Mechanism of Action Valacyclovir is a nucleoside analogue DNA polymerase inhibitor. Valacyclovir hydrochloride is rapidly converted to acyclovir which has demonstrated antiviral activity against HSV types 1 HSV─1 and 2 HSV─2 and VZV both in cell culture and in vivo. Valtrex Mechanism of Action After absorption from the intestinal tract, generic valacyclovir is converted to acyclovir triphosphate and amino acid valine in the liver. Acyclovir triphosphate inhibits replication of viral DNA polymerase, as it invades the viral DNA chain and upsets the DNA strand. Acyclovir Nursing Considerations, Side Effects and Mechanism of Action Pharmacology for Nurses. Diazepam Nursing Considerations, Side Effects, and Mechanism of Action Pharmacology for Nurses.

    Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to Acyclovir. It is marketed by Glaxo Smith Kline under the trade name Valtrex or Zelitrex. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism.

    Valtrex mechanism of action

    Valtrex Valacyclovir Hydrochloride Side Effects, Interactions., Valtrex® Generic Valacyclovir 500/1000 mg - Antiviral Drug

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  7. Mechanism of Action Reduce viral replication by inhibiting viral DNA polymerase. Pharmacokinetics Valacyclovir is a prodrug of, and metabolized to acyclovir; the oral bioavailability of acyclovir from valacyclovir is 54% as compared to 15-30% for acyclovir.

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    Valacyclovir is the primary active substance in Valtrex. The L-valyl ester of acyclovir is associated with excellent absorption and a significant concentration in the blood. Therefore, Valtrex demonstrates longer lasting effects compared with its analogs. Mechanism of action. accumulation exclusively in virus-infected cells; oppression of. Valacyclovir. Class Valacyclovir is a prodrug of acyclovir. Antiviral Activity Valacyclovir has activity against herpesviruses. Mechanism of Action Valacyclovir is. Valtrex. It is the brand name of a drug called valacyclovir, that belongs to a group of drugs called antivirals. This medication is manufactured by GlaxoSmithKline, a British pharmaceutical company with headquarters in London. In the United States, it is available as a generic drug since 2009. Mechanism of Action

     
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