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    You should not take this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, Hydro Diuril, Hyzaar, Vaseretic, Zestoretic and others), valsartan (Diovan), or sulfa drugs, or if you are unable to urinate. Before taking amlodipine, hydrochlorothiazide, and valsartan, tell your doctor if you have kidney or liver disease, congestive heart failure, glaucoma, asthma or allergies, low or high blood levels of potassium, gout, lupus, diabetes, or a pencillin allergy. Do not use this medication without telling your doctor if you are pregnant. Amlodipine, hydrochlorothiazide, and valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Stop using this medication and tell your doctor right away if you become pregnant during treatment. Amlodipine relaxes (widens) blood vessels and improves blood flow. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Valsartan is an angiotensin II receptor antagonists. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Hypersensitivity: Angioedema (rare), urticaria Digestive: Elevated liver enzymes, hepatitis (rare) Renal: Impaired renal function, renal failure Clinical laboratory tests: Hyperkalemia Dermatologic: Alopecia, bullous dermatitis Blood and lymphatic: Thrombocytopenia (rare) Vascular: Vasculitis Orthostatic hypotension risk: Initiate combination therapy with 2 antihypertensive drugs cautiously in patients with diabetes or autonomic dysfunction and in geriatric patients Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with a history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide) Avoid in severe renal impairment (ineffective) Use with caution in severe hepatic impairment Use with caution in renal artery stenosis; avoid in bilateral renal artery stenosis Cr Cl Valsartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II Hydrochlorothiazide: Thiazide diuretic that inhibits sodium reabsorption in distal renal tubules; results in increased excretion of sodium ions and water, as well as potassium and hydrogen ions The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

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    The main difference between Diovan and Diovan HCT is that Diovan contains one active ingredient valsartan, and Diovan HCT contains two valsartan an. Compare Valsartan HCT 80/12.5mg Diovan HCT prices from verified online pharmacies or local U. S. pharmacies. Print free coupons for Valsartan HCT, shop. Design & Evalution of Valsartan and Hydrochlorothiazide Coated Tablets by Adi. See more like this. Save up to 10% when you buy more. Was Previous Price $33.99.

    The recommended dose of Valsartan/hydrochlorothiazide 80 mg/12.5 mg is one film coated tablet once daily. Dose titration with the individual components is recommended. In each case, up- titration of individual components to the next dose should be followed in order to reduce the risk of hypotension and other adverse events. When clinically appropriate direct change from monotherapy to the fixed dose combination may be considered in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorothiazide monotherapy, provided the recommended dose titration sequence for the individual components is followed. The clinical response to Valsartan/hydrochlorothiazide should be evaluated after initiating therapy and if blood pressure remains uncontrolled, the dose may be increased by increasing either one of the components to a maximum dose of valsartan/hydrochlorothiazide 320 mg/25 mg. No dosage adjustment is required for patients with mild to moderate renal impairment (creatinine clearance ≥30 ml/min). Due to the hydrochlorothiazide component, Valsartan/hydrochlorothiazide is contraindicated in patients with severe renal impairment (see sections 4.3, 4.4 and 5.2). VALSARTAN/HYDROCHLOROTHIAZIDE 160 mg/12.5 mg FILM-COATED TABLETS PACKAGE LEAFLET: INFORMATION FOR THE USER Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you. This includes any possible side effects not listed in this leaflet. What you need to know before you take Valsartan/Hydrochlorothiazide 3. • Valsartan belongs to a class of medicines known as “angiotensin-II receptor antagonists”, which help to control high blood pressure. • If you have any further questions, ask your doctor or pharmacist. • If you get any of the side effects talk to your doctor or pharmacist. What Valsartan/Hydrochlorothiazide is and what it is used for 2. Both of these substances help to control high blood pressure (hypertension). It may harm them, even if their signs of illness are the same as yours. Contents of the pack and other information Version: 4 26 March 2015 1 What Valsartan/Hydrochlorothiazide is and what it is used for • Valsartan/Hydrochlorothiazide film-coated tablets contain two active substances called valsartan and hydrochlorothiazide. Angiotensin II is a substance in the body that causes vessels to tighten, thus causing your blood pressure to increase. Valsartan works by blocking the effect of angiotensin II. As a result, blood vessels relax and blood pressure is lowered. • Hydrochlorothiazide belongs to a group of medicines called thiazide diuretics (also known as “water tablets”).

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