It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Treatment of discoid lupus erythematosus with chloroquine Can plaquenil cause itchy face Jan 05, 2020 Age, liver disease, and genetic factors e.g. polymorphisms in the cytochrome P450 gene which may impact blood concentrations are thought to be lesser risk factors associated with toxicity risk. Kidney and liver disease predispose to hydroxychloroquine toxicity due to impaired clearance of the drug. Apr 10, 2019 Plaquenil can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis or HIV/AIDS; antidepressants or antipsychotic medicines; birth. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Plaquenil liver failure Plaquenil Side Effects Common, Severe, Long Term -, Plaquenil Uses, Dosage & Side Effects - Hydroxychloroquine 400 mg side effectsDoes plaquenil affect your heart The U. S. Food and Drug Administration FDA is adding information on severe liver injury to the Boxed Warning of Arava leflunomide – a drug used to treat rheumatoid arthritis - to. FDA Drug Safety Communication New boxed warning for severe liver.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Methotrexate or Plaquenil? DailyStrength. Find information about common, infrequent and rare side effects of Plaquenil Oral. My liver under and just beneath my right rib cage feels painful and swollen. The biologics are nasty too and my internist said 10 years is max on them as they are know to cause kidney/liver failure in his experience 42 years as an internist. I am not sure where to go from here. This is an awful disease. Diagnosed at 48. People taking Plaquenil for 5 or more years; people taking Plaquenil at higher doses than recommended; people who already have retinal disease; people who already have kidney or liver disease; people over 60 years old; people who lose a lot of weight while taking Plaquenil. Tell your doctor if this happens as your dose may need to be lowered.