Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil and oral pigmentation Plaquenil and numb tingling hands By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. Does it matter if you take 400 mg plaquenil hydroxychloroquine at once VS 200 in the morning and 200 in the afternoon? Is it normal to take plaquenil hydroxychloroquine for arthritis? How long does it take for plaquenil hydroxychloroquine to work with rashes? Is it possible for me to take tumeric complex if I take plaquenil. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss day, been taking for over a year now but although it helps with some of the pain. I have to have steroid. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Can i take plaquenil and methotrexate together Rheumatoid Arthritis Treatment Options Johns Hopkins., Can you take plaquenil hydroxychloroquine if you have. Plaquenil creamChloroquine lysosomal inhibitor transfection Severe Interactions These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. These medications may interact and cause very harmful effects. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. Plaquenil Oral Interactions with Other Medication. Does anyone take methotrexate and hydroxychloroquine.. Effects of methotrexate and hydroxychloroquine combination.. I am on Methotrexate and plaquenil, that help with the aches and pains. I also take 3 mgs of melatonin just before bed which helps so much, it may take a week or so before it is truly effective, I still wake early about 5 am but have learned to just lay and relax till time to get up. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine results from the double‐blind placebo‐controlled MASCOT study. which can be used to achieve tight control of rheumatoid arthritis. that the potent SASP.