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    Mechanism of action Fluconazole usually is fungistatic in action. Fluconazole and other triazole-derivative antifungal agents appear to have a mechanism of action similar to that of the imidazole-derivative antifungal agents. Like imidazoles, fluconazole presumably exerts its antifungal activity by altering cellular membranes resulting in increased membrane permeability, leakage of essential elements, and impaired uptake of precursor molecules. Although the exact mechanism of action of fluconazole and other triazoles has not been fully determined, the drugs inhibit cytochrome P-450 14-α-desmethylase in susceptible fungi, which leads to accumulation of C-14 methylated sterols (e.g., lanosterol) and decreased concentrations of ergosterol. It appears that this may occur because a nitrogen atom (N-4) in the triazole molecule binds to the heme iron of cytochrome P-450 14-α-desmethylase in susceptible fungi. Unlike some imidazoles that suppress ATP concentrations in intact cells and spheroplasts of C. albicans, fluconazole does not appear to have an appreciable effect on ATP concentrations in the organism. Fluconazole Diflucan - Side Effects, Dosage, Interactions - Drugs Apo-Fluconazole 150 - Uses, Side Effects, Interactions - FLUCONAZOLE 150MG CAPSULE
     
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    Fluconazole 150mg capsules are also available without a brand name, ie as the generic medicine. Vaginal thrush is the common term for infections of the vagina with Candida species of fungi, in particular Candida albicans. This infection causes inflammation and discharge from the vagina. In men it causes soreness and redness of the penis, tightness of the foreskin, or a white, odourless discharge from the penis. Fluconazole kills the Candida fungi causing the thrush infection by making holes appear in their cell membranes. This allows essential constituents of the fungal cells to out, which kills the fungi and clears up the infection. Medicines and their possible side effects can affect individual people in different ways. Fluconazole 150 mg capsules - Summary of Product Characteristics. FLUCONAZOLE 150 MG - ORAL Diflucan side effects, medical. Fluconazole MedlinePlus Drug Information
     
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